QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report

Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity...

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Autores principales: Ali, Zain, Khan, Mariya, Ullah, Waqas, Kpehor, Atsoufui A., Cheema, Muhammad Arslan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425623/
https://www.ncbi.nlm.nih.gov/pubmed/32850053
http://dx.doi.org/10.1080/20009666.2020.1749511
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author Ali, Zain
Khan, Mariya
Ullah, Waqas
Kpehor, Atsoufui A.
Cheema, Muhammad Arslan
author_facet Ali, Zain
Khan, Mariya
Ullah, Waqas
Kpehor, Atsoufui A.
Cheema, Muhammad Arslan
author_sort Ali, Zain
collection PubMed
description Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity manifesting with two rare but potentially life-threatening complications, rhabdomyolysis, and QT prolongation. Laboratory testing for diphenhydramine levels are not widely available. We recommend a high degree of suspicion for these complications when evaluating patients with diphenhydramine overdose, to adequately manage and prevent untoward outcomes.
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spelling pubmed-74256232020-08-25 QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report Ali, Zain Khan, Mariya Ullah, Waqas Kpehor, Atsoufui A. Cheema, Muhammad Arslan J Community Hosp Intern Med Perspect Case Report Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity manifesting with two rare but potentially life-threatening complications, rhabdomyolysis, and QT prolongation. Laboratory testing for diphenhydramine levels are not widely available. We recommend a high degree of suspicion for these complications when evaluating patients with diphenhydramine overdose, to adequately manage and prevent untoward outcomes. Taylor & Francis 2020-05-21 /pmc/articles/PMC7425623/ /pubmed/32850053 http://dx.doi.org/10.1080/20009666.2020.1749511 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ali, Zain
Khan, Mariya
Ullah, Waqas
Kpehor, Atsoufui A.
Cheema, Muhammad Arslan
QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
title QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
title_full QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
title_fullStr QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
title_full_unstemmed QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
title_short QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
title_sort qt interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425623/
https://www.ncbi.nlm.nih.gov/pubmed/32850053
http://dx.doi.org/10.1080/20009666.2020.1749511
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