Cargando…

Crosstalk between EP2 and PPARα Modulates Hypoxic Signaling and Myopia Development in Guinea Pigs

PURPOSE: Cyclic adenosine monophosphate (cAMP) and peroxisome proliferator-activated receptor alpha (PPARα) levels mediate extracellular matrix (ECM) changes by altering the levels of hypoxia-inducible factor 1-alpha (HIF-1α) in various tissues. We aimed to determine, in the sclera of guinea pigs, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Srinivasalu, Nethrajeith, Zhang, Sen, Xu, Renchang, Reinach, Peter Sol, Su, Yongchao, Zhu, Yun, Qu, Jia, Zhou, Xiangtian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425689/ https://www.ncbi.nlm.nih.gov/pubmed/32725213 http://dx.doi.org/10.1167/iovs.61.8.44

Ejemplares similares

Calcipotriol Attenuates Form Deprivation Myopia Through a Signaling Pathway Parallel to TGF-β2–Induced Increases in Collagen Expression
por: Jiao, Shiming, et al.
Publicado: (2023)

Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs
por: Zhou, Xuan, et al.
Publicado: (2020)

Gene Expression Signatures of Contact Lens-Induced Myopia in Guinea Pig Retinal Pigment Epithelium
por: Goto, So, et al.
Publicado: (2022)

Temporal bright light at low frequency retards lens-induced myopia in guinea pigs
por: Deng, Baodi, et al.
Publicado: (2023)

Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs
por: Yang, Jinglei, et al.
Publicado: (2017)

Hypoxia-Induced Scleral HIF-2α Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice
por: Wu, Wenjing, et al.
Publicado: (2022)

Decreased Choroidal Blood Perfusion Induces Myopia in Guinea Pigs
por: Zhou, Xuan, et al.
Publicado: (2021)

Effect of vascular endothelial growth factor 165 on dopamine level in the retinas of guinea pigs with form-deprivation myopia
por: Sun, Ruiting, et al.
Publicado: (2023)

The Role of the Dopamine D2 Receptor in Form-Deprivation Myopia in Mice: Studies With Full and Partial D2 Receptor Agonists and Knockouts
por: Huang, Furong, et al.
Publicado: (2020)

Spontaneously Myopic Guinea Pig: Model of Early Pathologic Myopia
por: Zhang, Yue, et al.
Publicado: (2023)

Changes in protein profiles of guinea pig sclera during development of form deprivation myopia and recovery
por: Zhou, Xiangtian, et al.
Publicado: (2010)

Choroidal blood perfusion as a potential “rapid predictive index” for myopia development and progression
por: Zhou, Xiangtian, et al.
Publicado: (2021)

Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs
por: Dong, Feng, et al.
Publicado: (2011)

Topical Application of Bunazosin Hydrochloride Suppresses Myopia Progression With an Increase in Choroidal Blood Perfusion
por: Jeong, Heonuk, et al.
Publicado: (2023)

Retinoschisin and Cardiac Glycoside Crosstalk at the Retinal Na/K-ATPase
por: Schmid, Verena, et al.
Publicado: (2020)

The regulation of immune checkpoints by the hypoxic tumor microenvironment
por: Hu, Min, et al.
Publicado: (2021)

Intravitreal brimonidine inhibits form-deprivation myopia in guinea pigs
por: Yang, Yifang, et al.
Publicado: (2021)

Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin
por: Lin, Yong, et al.
Publicado: (2022)

The RNA m(5)C Methylase NSUN2 Modulates Corneal Epithelial Wound Healing
por: Luo, Guangying, et al.
Publicado: (2023)

Destabilization of EpCAM dimer is associated with increased susceptibility towards cleavage by TACE
por: Žagar, Tomaž, et al.
Publicado: (2021)

Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis
por: Zhao, Fei, et al.
Publicado: (2020)

Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage
por: Li, Jiao, et al.
Publicado: (2022)

A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes
por: Gschweitl, Michaela, et al.
Publicado: (2016)

Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy
por: Zhang, Juanjuan, et al.
Publicado: (2021)

Effects of Topical Latanoprost on Intraocular Pressure and Myopia Progression in Young Guinea Pigs
por: El-Nimri, Nevin W., et al.
Publicado: (2018)

A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model
por: Garcia, Mariana B., et al.
Publicado: (2017)

Widespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs
por: Feng, Jiaojiao, et al.
Publicado: (2023)

The Role of Retinal Connexins Cx36 and Horizontal Cell Coupling in Emmetropization in Guinea Pigs
por: Zhi, Zhina, et al.
Publicado: (2021)

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ
por: Watanabe, Masashi, et al.
Publicado: (2015)

Increased Expression of CCN2 in the Red Flashing Light-Induced Myopia in Guinea Pigs
por: Wang, Hong, et al.
Publicado: (2013)

Strain-Dependent Differences in Sensitivity to Myopia-Inducing Stimuli in Guinea Pigs and Role of Choroid
por: Jiang, Liqin, et al.
Publicado: (2019)

Co-existence of myopia and amblyopia in a guinea pig model with monocular form deprivation
por: Tian, Lu, et al.
Publicado: (2021)

Effects of exogenous retinoic acid on ocular parameters in Guinea pigs with form deprivation myopia
por: Wu, Yajun, et al.
Publicado: (2023)

Comprehensive miRNA expression profiles in the ilea of Lawsonia intracellularis-infected pigs
por: LI, Hongyi, et al.
Publicado: (2016)

Morphologic and biochemical changes in the retina and sclera induced by form deprivation high myopia in guinea pigs
por: Zi, Yingxin, et al.
Publicado: (2020)

Electroacupuncture Improves Choroidal Blood Flow to Inhibit the Development of Lens-Induced Myopia in Guinea Pigs
por: Yu, Ting, et al.
Publicado: (2022)

Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and Transcytosis
por: Nersisyan, S. A.
Publicado: (2022)

An efficient method for saliva collection from mature pigs to determine their enzymatic and electrolytic profiles
por: AKHTAR, Nadeem, et al.
Publicado: (2017)

Bidirectional crosstalk between epithelial–mesenchymal plasticity and IFNγ-induced PD-L1 expression promotes tumour progression
por: Burger, Gerhard A., et al.
Publicado: (2022)

Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated
por: Liu, Zhen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i8f5angun01de93scq3tl799ec