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Development of Animal Models for Lens and Corneal Diseases Using N-Methyl-N-Nitrosourea

PURPOSE: N-methyl-N-nitrosourea (MNU) is an alkylating toxicant with potent mutagenic ability. This study was designed to induce apoptosis in lens epithelial cells (LECs) and corneal endothelial cells (CECs) via MNU administration. We sought to build ocular disease models of cataract and corneal end...

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Detalles Bibliográficos
Autores principales:	Qu, Yingxin, Li, Runpu, Li, Xiaoqi, Yang, Qinghua, Chen, Jianwen, Dong, Yan, Xiao, Wentian, Zheng, Shuo, Wang, Liqiang, Tao, Ye, Huang, Yifei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Physiology and Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425732/ https://www.ncbi.nlm.nih.gov/pubmed/32721019 http://dx.doi.org/10.1167/iovs.61.8.38

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