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Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study
PURPOSE: To investigate retinal neurovascular structural changes in patients with essential hypertension. METHODS: This observational cross-sectional study consisted of 199 right eyes from 169 nondiabetic essential hypertensive patients, divided into groups as follows: group A, 113 patients with hyp...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425736/ https://www.ncbi.nlm.nih.gov/pubmed/32725211 http://dx.doi.org/10.1167/iovs.61.8.42 |
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author | Peng, Qingsheng Hu, Yijun Huang, Manqing Wu, Ying Zhong, Pingting Dong, Xinran Wu, Qiaowei Liu, Baoyi Li, Cong Xie, Jinxian Kuang, Yu Yu, Danqing Yu, Honghua Yang, Xiaohong |
author_facet | Peng, Qingsheng Hu, Yijun Huang, Manqing Wu, Ying Zhong, Pingting Dong, Xinran Wu, Qiaowei Liu, Baoyi Li, Cong Xie, Jinxian Kuang, Yu Yu, Danqing Yu, Honghua Yang, Xiaohong |
author_sort | Peng, Qingsheng |
collection | PubMed |
description | PURPOSE: To investigate retinal neurovascular structural changes in patients with essential hypertension. METHODS: This observational cross-sectional study consisted of 199 right eyes from 169 nondiabetic essential hypertensive patients, divided into groups as follows: group A, 113 patients with hypertensive retinopathy (HTNR); group B, 56 patients without HTNR; and a control group of 30 healthy subjects. Peripapillary retinal nerve fiber layer (RNFL), radial peripapillary segmented (RPC), ganglion cell–inner plexiform layer (GC-IPL), and superficial (SVP) and deep (DVP) vascular plexus density at the macula (6 × 6 mm(2)) were measured by optical coherence tomography angiography (OCTA). RESULTS: DVP density was significantly reduced in groups A and B compared to the control group (group A DVP, P = 0.001; group B DVP P = 0.002). GC-IPL, RNFL thickness, and RPC and SVP density in group A were significantly decreased compared to the control group or group B (all P < 0.05). In hypertensive patients, GC-IPL and RNFL thickness were negatively correlated with severity of HTNR (GC-IPL, r = –0.331, P < 0.001; RNFL, r = –0.583, P < 0.001) and level of home blood pressure monitoring (HBPM) (GC-IPL, r = –0.160, P = 0.050; RNFL, r = –0.282, P = 0.001) and were positively correlated with SVP (GC-IPL, r = 0.267, P = 0.002; RNFL, r = 0.361, P < 0.001) and RPC density (GC-IPL, r = 0.298, P < 0.001; RNFL, r = 0.663, P < 0.001). Among subjects with grade 2 or 3 retinopathy, the superior RNFL was significantly thinner in patients with high HBPM level than in those with normal HBPM level (grade 2, P = 0.016; grade 3, P = 0.006). CONCLUSIONS: Reduction of retinal vessel density and RNFL thickness is observed in patients with HTNR and is inversely associated with level of HBPM. |
format | Online Article Text |
id | pubmed-7425736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-74257362020-08-26 Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study Peng, Qingsheng Hu, Yijun Huang, Manqing Wu, Ying Zhong, Pingting Dong, Xinran Wu, Qiaowei Liu, Baoyi Li, Cong Xie, Jinxian Kuang, Yu Yu, Danqing Yu, Honghua Yang, Xiaohong Invest Ophthalmol Vis Sci Clinical and Epidemiologic Research PURPOSE: To investigate retinal neurovascular structural changes in patients with essential hypertension. METHODS: This observational cross-sectional study consisted of 199 right eyes from 169 nondiabetic essential hypertensive patients, divided into groups as follows: group A, 113 patients with hypertensive retinopathy (HTNR); group B, 56 patients without HTNR; and a control group of 30 healthy subjects. Peripapillary retinal nerve fiber layer (RNFL), radial peripapillary segmented (RPC), ganglion cell–inner plexiform layer (GC-IPL), and superficial (SVP) and deep (DVP) vascular plexus density at the macula (6 × 6 mm(2)) were measured by optical coherence tomography angiography (OCTA). RESULTS: DVP density was significantly reduced in groups A and B compared to the control group (group A DVP, P = 0.001; group B DVP P = 0.002). GC-IPL, RNFL thickness, and RPC and SVP density in group A were significantly decreased compared to the control group or group B (all P < 0.05). In hypertensive patients, GC-IPL and RNFL thickness were negatively correlated with severity of HTNR (GC-IPL, r = –0.331, P < 0.001; RNFL, r = –0.583, P < 0.001) and level of home blood pressure monitoring (HBPM) (GC-IPL, r = –0.160, P = 0.050; RNFL, r = –0.282, P = 0.001) and were positively correlated with SVP (GC-IPL, r = 0.267, P = 0.002; RNFL, r = 0.361, P < 0.001) and RPC density (GC-IPL, r = 0.298, P < 0.001; RNFL, r = 0.663, P < 0.001). Among subjects with grade 2 or 3 retinopathy, the superior RNFL was significantly thinner in patients with high HBPM level than in those with normal HBPM level (grade 2, P = 0.016; grade 3, P = 0.006). CONCLUSIONS: Reduction of retinal vessel density and RNFL thickness is observed in patients with HTNR and is inversely associated with level of HBPM. The Association for Research in Vision and Ophthalmology 2020-07-29 /pmc/articles/PMC7425736/ /pubmed/32725211 http://dx.doi.org/10.1167/iovs.61.8.42 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Clinical and Epidemiologic Research Peng, Qingsheng Hu, Yijun Huang, Manqing Wu, Ying Zhong, Pingting Dong, Xinran Wu, Qiaowei Liu, Baoyi Li, Cong Xie, Jinxian Kuang, Yu Yu, Danqing Yu, Honghua Yang, Xiaohong Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study |
title | Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study |
title_full | Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study |
title_fullStr | Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study |
title_full_unstemmed | Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study |
title_short | Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study |
title_sort | retinal neurovascular impairment in patients with essential hypertension: an optical coherence tomography angiography study |
topic | Clinical and Epidemiologic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425736/ https://www.ncbi.nlm.nih.gov/pubmed/32725211 http://dx.doi.org/10.1167/iovs.61.8.42 |
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