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Mutations in m(6)A consensus motifs are suppressed in the m(6)A modified genes in human cancer cells
N(6)-methyladenosine (m(6)A) is the most prevalent type of RNA modification. METTL3 in the methyltransferase complex is the core enzyme responsible for methylation. METTL3 selectively catalyzes the adenosines centered in the RRAC motif. Functional studies established that m(6)A could enhance the tra...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425885/ https://www.ncbi.nlm.nih.gov/pubmed/32790688 http://dx.doi.org/10.1371/journal.pone.0236882 |