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Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

Nanodiscs are membrane mimetics that consist of a protein belt surrounding a lipid bilayer, and are broadly used for characterization of membrane proteins. Here, we investigate the structure, dynamics and biophysical properties of two small nanodiscs, MSP1D1ΔH5 and ΔH4H5. We combine our SAXS and SAN...

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Detalles Bibliográficos
Autores principales:	Bengtsen, Tone, Holm, Viktor L, Kjølbye, Lisbeth Ravnkilde, Midtgaard, Søren R, Johansen, Nicolai Tidemand, Tesei, Giulio, Bottaro, Sandro, Schiøtt, Birgit, Arleth, Lise, Lindorff-Larsen, Kresten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426092/ https://www.ncbi.nlm.nih.gov/pubmed/32729831 http://dx.doi.org/10.7554/eLife.56518

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