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Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital

Context  Venous or arterial blood is used for the estimation of electrolytes in neonates in neonatal intensive care unit (NICU). In addition to the measurement of blood gases and bicarbonate in the arterial blood, arterial blood gas analysis also estimates electrolytes thus circumventing the need to...

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Autores principales: Doddamani, Parveen, Kasapura Shivashankar, Kusuma, Chikkavaddaragudi Ramachandra, Shobha, Aman, Insha, Maduvanahalli Nataraj, Suma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Private Ltd. 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426183/
https://www.ncbi.nlm.nih.gov/pubmed/32801580
http://dx.doi.org/10.1055/s-0040-1713061
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author Doddamani, Parveen
Kasapura Shivashankar, Kusuma
Chikkavaddaragudi Ramachandra, Shobha
Aman, Insha
Maduvanahalli Nataraj, Suma
author_facet Doddamani, Parveen
Kasapura Shivashankar, Kusuma
Chikkavaddaragudi Ramachandra, Shobha
Aman, Insha
Maduvanahalli Nataraj, Suma
author_sort Doddamani, Parveen
collection PubMed
description Context  Venous or arterial blood is used for the estimation of electrolytes in neonates in neonatal intensive care unit (NICU). In addition to the measurement of blood gases and bicarbonate in the arterial blood, arterial blood gas analysis also estimates electrolytes thus circumventing the need to collect a venous sample for electrolytes. The literature survey revealed studies comparing the electrolyte levels in arterial and venous blood in adults and older children, but to our knowledge none were found in neonates, hence the study. Aims  The aim of the study is to compare the electrolytes in arterial and venous samples in neonates in a critical care set up and derive in-house prediction equation to correlate the arterial and venous electrolytes. Settings and Design  Hospital-based, retrospective cross-sectional study done in critically ill neonates. Materials and Methods  All the newborns (age ≤28 days) admitted in NICU from July 2016 to June 2018 were selected for the study and data collected with the help of Hospital Information System. Statistical Analysis  MedCalc and NCSS 12 (trial version) software was used. Deming Regression and Bland Altman analysis were performed. Results  A strong positive correlation between the arterial and venous blood electrolytes observed. An in-house prediction equation was derived for the venous electrolytes. Deming regression analysis showed that only potassium levels are statistically equivalent between the instruments and the sample type. Bland Altman Analysis between the arterial and venous electrolytes showed a mean difference which was well within the accepted Clinical Laboratory Improvement Amendment guidelines. Conclusion  The electrolyte levels estimated by arterial blood in neonates can be used in an interchangeable manner only for potassium levels, whereas sodium and chloride estimation necessitates one to be cautious.
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spelling pubmed-74261832020-08-14 Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital Doddamani, Parveen Kasapura Shivashankar, Kusuma Chikkavaddaragudi Ramachandra, Shobha Aman, Insha Maduvanahalli Nataraj, Suma J Lab Physicians Context  Venous or arterial blood is used for the estimation of electrolytes in neonates in neonatal intensive care unit (NICU). In addition to the measurement of blood gases and bicarbonate in the arterial blood, arterial blood gas analysis also estimates electrolytes thus circumventing the need to collect a venous sample for electrolytes. The literature survey revealed studies comparing the electrolyte levels in arterial and venous blood in adults and older children, but to our knowledge none were found in neonates, hence the study. Aims  The aim of the study is to compare the electrolytes in arterial and venous samples in neonates in a critical care set up and derive in-house prediction equation to correlate the arterial and venous electrolytes. Settings and Design  Hospital-based, retrospective cross-sectional study done in critically ill neonates. Materials and Methods  All the newborns (age ≤28 days) admitted in NICU from July 2016 to June 2018 were selected for the study and data collected with the help of Hospital Information System. Statistical Analysis  MedCalc and NCSS 12 (trial version) software was used. Deming Regression and Bland Altman analysis were performed. Results  A strong positive correlation between the arterial and venous blood electrolytes observed. An in-house prediction equation was derived for the venous electrolytes. Deming regression analysis showed that only potassium levels are statistically equivalent between the instruments and the sample type. Bland Altman Analysis between the arterial and venous electrolytes showed a mean difference which was well within the accepted Clinical Laboratory Improvement Amendment guidelines. Conclusion  The electrolyte levels estimated by arterial blood in neonates can be used in an interchangeable manner only for potassium levels, whereas sodium and chloride estimation necessitates one to be cautious. Thieme Medical and Scientific Publishers Private Ltd. 2020-03 2020-06-15 /pmc/articles/PMC7426183/ /pubmed/32801580 http://dx.doi.org/10.1055/s-0040-1713061 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Doddamani, Parveen
Kasapura Shivashankar, Kusuma
Chikkavaddaragudi Ramachandra, Shobha
Aman, Insha
Maduvanahalli Nataraj, Suma
Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital
title Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital
title_full Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital
title_fullStr Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital
title_full_unstemmed Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital
title_short Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital
title_sort agreement of measurement between arterial and venous electrolyte levels in neonates in a tertiary care hospital
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426183/
https://www.ncbi.nlm.nih.gov/pubmed/32801580
http://dx.doi.org/10.1055/s-0040-1713061
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