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Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
PURPOSE: The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. METHODS: Multivariate logistic regression model and Kaplan–Meier sur...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426229/ https://www.ncbi.nlm.nih.gov/pubmed/32798701 http://dx.doi.org/10.1016/j.annepidem.2020.08.005 |
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author | Parra-Bracamonte, Gaspar Manuel Lopez-Villalobos, Nicolas Parra-Bracamonte, Francisco E. |
author_facet | Parra-Bracamonte, Gaspar Manuel Lopez-Villalobos, Nicolas Parra-Bracamonte, Francisco E. |
author_sort | Parra-Bracamonte, Gaspar Manuel |
collection | PubMed |
description | PURPOSE: The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. METHODS: Multivariate logistic regression model and Kaplan–Meier survival curves were fitted to study odds of death of characteristics and comorbidities in patients with COVID-19 in Mexico. RESULTS: Age, sex, and the most frequent comorbidities diabetes, obesity, and hypertension were significantly associated to the risk of death by COVID-19 (P < .0001). Smoking habit was not identified as a risk factor for death. Less-frequent comorbidities such as chronic obstructive pulmonary disease, chronic kidney disease, and patients with immunosuppressed conditions also showed a significant risk for death (P < .0001). Hospitalized patients and those with pneumonia had serious risks for mortality (P < .0001), and more attention to specific conditions might be considered during clinical admission. CONCLUSIONS: A more vulnerable positive patient is depicted by a male patient, older than 41 years, which increases their risk with more prevalent comorbidities such as diabetes, hypertension, and obesity. Some implications on outcomes are discussed. |
format | Online Article Text |
id | pubmed-7426229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74262292020-08-14 Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico Parra-Bracamonte, Gaspar Manuel Lopez-Villalobos, Nicolas Parra-Bracamonte, Francisco E. Ann Epidemiol Original Article PURPOSE: The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. METHODS: Multivariate logistic regression model and Kaplan–Meier survival curves were fitted to study odds of death of characteristics and comorbidities in patients with COVID-19 in Mexico. RESULTS: Age, sex, and the most frequent comorbidities diabetes, obesity, and hypertension were significantly associated to the risk of death by COVID-19 (P < .0001). Smoking habit was not identified as a risk factor for death. Less-frequent comorbidities such as chronic obstructive pulmonary disease, chronic kidney disease, and patients with immunosuppressed conditions also showed a significant risk for death (P < .0001). Hospitalized patients and those with pneumonia had serious risks for mortality (P < .0001), and more attention to specific conditions might be considered during clinical admission. CONCLUSIONS: A more vulnerable positive patient is depicted by a male patient, older than 41 years, which increases their risk with more prevalent comorbidities such as diabetes, hypertension, and obesity. Some implications on outcomes are discussed. Elsevier Inc. 2020-12 2020-08-14 /pmc/articles/PMC7426229/ /pubmed/32798701 http://dx.doi.org/10.1016/j.annepidem.2020.08.005 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Parra-Bracamonte, Gaspar Manuel Lopez-Villalobos, Nicolas Parra-Bracamonte, Francisco E. Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico |
title | Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico |
title_full | Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico |
title_fullStr | Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico |
title_full_unstemmed | Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico |
title_short | Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico |
title_sort | clinical characteristics and risk factors for mortality of patients with covid-19 in a large data set from mexico |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426229/ https://www.ncbi.nlm.nih.gov/pubmed/32798701 http://dx.doi.org/10.1016/j.annepidem.2020.08.005 |
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