Cargando…

Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico

PURPOSE: The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. METHODS: Multivariate logistic regression model and Kaplan–Meier sur...

Descripción completa

Detalles Bibliográficos
Autores principales: Parra-Bracamonte, Gaspar Manuel, Lopez-Villalobos, Nicolas, Parra-Bracamonte, Francisco E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426229/
https://www.ncbi.nlm.nih.gov/pubmed/32798701
http://dx.doi.org/10.1016/j.annepidem.2020.08.005
_version_ 1783570641642848256
author Parra-Bracamonte, Gaspar Manuel
Lopez-Villalobos, Nicolas
Parra-Bracamonte, Francisco E.
author_facet Parra-Bracamonte, Gaspar Manuel
Lopez-Villalobos, Nicolas
Parra-Bracamonte, Francisco E.
author_sort Parra-Bracamonte, Gaspar Manuel
collection PubMed
description PURPOSE: The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. METHODS: Multivariate logistic regression model and Kaplan–Meier survival curves were fitted to study odds of death of characteristics and comorbidities in patients with COVID-19 in Mexico. RESULTS: Age, sex, and the most frequent comorbidities diabetes, obesity, and hypertension were significantly associated to the risk of death by COVID-19 (P < .0001). Smoking habit was not identified as a risk factor for death. Less-frequent comorbidities such as chronic obstructive pulmonary disease, chronic kidney disease, and patients with immunosuppressed conditions also showed a significant risk for death (P < .0001). Hospitalized patients and those with pneumonia had serious risks for mortality (P < .0001), and more attention to specific conditions might be considered during clinical admission. CONCLUSIONS: A more vulnerable positive patient is depicted by a male patient, older than 41 years, which increases their risk with more prevalent comorbidities such as diabetes, hypertension, and obesity. Some implications on outcomes are discussed.
format Online
Article
Text
id pubmed-7426229
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-74262292020-08-14 Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico Parra-Bracamonte, Gaspar Manuel Lopez-Villalobos, Nicolas Parra-Bracamonte, Francisco E. Ann Epidemiol Original Article PURPOSE: The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. METHODS: Multivariate logistic regression model and Kaplan–Meier survival curves were fitted to study odds of death of characteristics and comorbidities in patients with COVID-19 in Mexico. RESULTS: Age, sex, and the most frequent comorbidities diabetes, obesity, and hypertension were significantly associated to the risk of death by COVID-19 (P < .0001). Smoking habit was not identified as a risk factor for death. Less-frequent comorbidities such as chronic obstructive pulmonary disease, chronic kidney disease, and patients with immunosuppressed conditions also showed a significant risk for death (P < .0001). Hospitalized patients and those with pneumonia had serious risks for mortality (P < .0001), and more attention to specific conditions might be considered during clinical admission. CONCLUSIONS: A more vulnerable positive patient is depicted by a male patient, older than 41 years, which increases their risk with more prevalent comorbidities such as diabetes, hypertension, and obesity. Some implications on outcomes are discussed. Elsevier Inc. 2020-12 2020-08-14 /pmc/articles/PMC7426229/ /pubmed/32798701 http://dx.doi.org/10.1016/j.annepidem.2020.08.005 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Parra-Bracamonte, Gaspar Manuel
Lopez-Villalobos, Nicolas
Parra-Bracamonte, Francisco E.
Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
title Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
title_full Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
title_fullStr Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
title_full_unstemmed Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
title_short Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
title_sort clinical characteristics and risk factors for mortality of patients with covid-19 in a large data set from mexico
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426229/
https://www.ncbi.nlm.nih.gov/pubmed/32798701
http://dx.doi.org/10.1016/j.annepidem.2020.08.005
work_keys_str_mv AT parrabracamontegasparmanuel clinicalcharacteristicsandriskfactorsformortalityofpatientswithcovid19inalargedatasetfrommexico
AT lopezvillalobosnicolas clinicalcharacteristicsandriskfactorsformortalityofpatientswithcovid19inalargedatasetfrommexico
AT parrabracamontefranciscoe clinicalcharacteristicsandriskfactorsformortalityofpatientswithcovid19inalargedatasetfrommexico