Degradation of Serrate via ubiquitin-independent 20S proteasome to survey RNA metabolism

Serrate (SE) is a key factor in RNA metabolism. Here, we report that SE binds 20S core proteasome α subunit G1 (PAG1) among other components and is accumulated in their mutants. Purified PAG1-containing 20S proteasome degrades recombinant SE via an ATP- and ubiquitin-independent manner in vitro. Not...

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Detalles Bibliográficos
Autores principales: Li, Yanjun, Sun, Di, Ma, Zeyang, Yamaguchi, Karissa, Wang, Lin, Zhong, Songxiao, Yan, Xingxing, Shang, Baoshuan, Nagashima, Yukihiro, Koiwa, Hisashi, Han, Jiajia, Xie, Qi, Zhou, Mingguo, Wang, Zhiye, Zhang, Xiuren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426255/
https://www.ncbi.nlm.nih.gov/pubmed/32690892
http://dx.doi.org/10.1038/s41477-020-0721-4

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