p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth

The ARHGAP35 gene encoding p190A RhoGAP (p190A) is significantly altered by both mutation and allelic deletion in human cancer, but the functional implications of such alterations are not known. Here, we demonstrate for the first time that p190A is a tumor suppressor using a xenograft mouse model wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ouyang, Hanyue, Luong, Phi, Frödin, Morten, Hansen, Steen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426264/
https://www.ncbi.nlm.nih.gov/pubmed/32641858
http://dx.doi.org/10.1038/s41388-020-1385-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426264/
https://www.ncbi.nlm.nih.gov/pubmed/32641858
http://dx.doi.org/10.1038/s41388-020-1385-2

Ejemplares similares