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Advancements in the co-formulation of biologic therapeutics

Biologic therapeutics are the medicines of the future and are destined to transform the approaches by which the causes and symptoms of diseases are cured and alleviated. These approaches will be accelerated through the development of novel strategies that target multiple pharmacologically active sit...

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Detalles Bibliográficos
Autores principales: Chauhan, Veeren M., Zhang, Hongyu, Dalby, Paul A., Aylott, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426274/
https://www.ncbi.nlm.nih.gov/pubmed/32798639
http://dx.doi.org/10.1016/j.jconrel.2020.08.013
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author Chauhan, Veeren M.
Zhang, Hongyu
Dalby, Paul A.
Aylott, Jonathan W.
author_facet Chauhan, Veeren M.
Zhang, Hongyu
Dalby, Paul A.
Aylott, Jonathan W.
author_sort Chauhan, Veeren M.
collection PubMed
description Biologic therapeutics are the medicines of the future and are destined to transform the approaches by which the causes and symptoms of diseases are cured and alleviated. These approaches will be accelerated through the development of novel strategies that target multiple pharmacologically active sites using a combination of different biologics, or mixtures of biologics and small molecule therapeutics. However, for this potential to be realised, advancements in co-formulation strategies for biologic therapeutics must be established. This review describes the current and emerging developments within this field and highlights the challenges and potential solutions, that will pave-the-way towards their clinical translation.
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spelling pubmed-74262742020-08-14 Advancements in the co-formulation of biologic therapeutics Chauhan, Veeren M. Zhang, Hongyu Dalby, Paul A. Aylott, Jonathan W. J Control Release Review Article Biologic therapeutics are the medicines of the future and are destined to transform the approaches by which the causes and symptoms of diseases are cured and alleviated. These approaches will be accelerated through the development of novel strategies that target multiple pharmacologically active sites using a combination of different biologics, or mixtures of biologics and small molecule therapeutics. However, for this potential to be realised, advancements in co-formulation strategies for biologic therapeutics must be established. This review describes the current and emerging developments within this field and highlights the challenges and potential solutions, that will pave-the-way towards their clinical translation. The Authors. Published by Elsevier B.V. 2020-11-10 2020-08-14 /pmc/articles/PMC7426274/ /pubmed/32798639 http://dx.doi.org/10.1016/j.jconrel.2020.08.013 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Chauhan, Veeren M.
Zhang, Hongyu
Dalby, Paul A.
Aylott, Jonathan W.
Advancements in the co-formulation of biologic therapeutics
title Advancements in the co-formulation of biologic therapeutics
title_full Advancements in the co-formulation of biologic therapeutics
title_fullStr Advancements in the co-formulation of biologic therapeutics
title_full_unstemmed Advancements in the co-formulation of biologic therapeutics
title_short Advancements in the co-formulation of biologic therapeutics
title_sort advancements in the co-formulation of biologic therapeutics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426274/
https://www.ncbi.nlm.nih.gov/pubmed/32798639
http://dx.doi.org/10.1016/j.jconrel.2020.08.013
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