Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

SUGCT (C7orf10) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied in vivo. Although mutations in Sugct lead to Glutaric Aciduria Type 3 disease in humans, patients remain largely asymptomatic despite high levels of...

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Detalles Bibliográficos
Autores principales: Niska-Blakie, Joanna, Gopinathan, Lakshmi, Low, Kia Ngee, Kien, Yang Lay, Goh, Christine M. F., Caldez, Matias J., Pfeiffenberger, Elisabeth, Jones, Oliver S., Ong, Chee Bing, Kurochkin, Igor V., Coppola, Vincenzo, Tessarollo, Lino, Choi, Hyungwon, Kanagasundaram, Yoganathan, Eisenhaber, Frank, Maurer-Stroh, Sebastian, Kaldis, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426296/
https://www.ncbi.nlm.nih.gov/pubmed/31722069
http://dx.doi.org/10.1007/s00018-019-03359-z

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