Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease. These small, soluble aggr...

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Detalles Bibliográficos
Autores principales: Limbocker, Ryan, Mannini, Benedetta, Ruggeri, Francesco S., Cascella, Roberta, Xu, Catherine K., Perni, Michele, Chia, Sean, Chen, Serene W., Habchi, Johnny, Bigi, Alessandra, Kreiser, Ryan P., Wright, Aidan K., Albright, J. Alex, Kartanas, Tadas, Kumita, Janet R., Cremades, Nunilo, Zasloff, Michael, Cecchi, Cristina, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426408/
https://www.ncbi.nlm.nih.gov/pubmed/32792544
http://dx.doi.org/10.1038/s42003-020-01140-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426408/
https://www.ncbi.nlm.nih.gov/pubmed/32792544
http://dx.doi.org/10.1038/s42003-020-01140-8

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