A candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against Leishmania infantum infection

Leishmaniases are neglected diseases caused by infection with Leishmania parasites and there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic recombinant vaccine against visceral leishmaniasis (VL) called ChimeraT, which contains specific T-cell epitopes from...

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Detalles Bibliográficos
Autores principales: Lage, Daniela P., Ribeiro, Patrícia A. F., Dias, Daniel S., Mendonça, Débora V. C., Ramos, Fernanda F., Carvalho, Lívia M., de Oliveira, Daysiane, Steiner, Bethina T., Martins, Vívian T., Perin, Luísa, Machado, Amanda S., Santos, Thaís T. O., Tavares, Grasiele S. V., Oliveira-da-Silva, João A., Oliveira, Jamil S., Roatt, Bruno M., Machado-de-Ávila, Ricardo A., Teixeira, Antônio L., Humbert, Maria V., Coelho, Eduardo A. F., Christodoulides, Myron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426426/
https://www.ncbi.nlm.nih.gov/pubmed/32821440
http://dx.doi.org/10.1038/s41541-020-00224-0

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