Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can initiate the alternative complement pathway (...

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Detalles Bibliográficos
Autores principales: Lammerts, Rosa G. M., Talsma, Ditmer T., Dam, Wendy A., Daha, Mohamed R., Seelen, Marc A. J., Berger, Stefan P., van den Born, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426487/
https://www.ncbi.nlm.nih.gov/pubmed/32849563
http://dx.doi.org/10.3389/fimmu.2020.01643

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