Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation

We report a case with extramedullary tumors affecting the supraclavicular region that presented as a relapse of acute myeloid leukemia (AML) with FLT3-ITD mutation after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Treatment with gilteritinib resulted in remarkable response with d...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumode, Takahiro, Rai, Shinya, Tanaka, Hirokazu, Espinoza, J. Luis, Kakutani, Hiroaki, Watatani, Yosaku, Minamoto, Shuji, Taniguchi, Yasuhiro, Nakayama, Shoko, Morita, Yasuyoshi, Ashida, Takashi, Matsumura, Itaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426564/
https://www.ncbi.nlm.nih.gov/pubmed/32817816
http://dx.doi.org/10.1016/j.lrr.2020.100219
_version_ 1783570711807262720
author Kumode, Takahiro
Rai, Shinya
Tanaka, Hirokazu
Espinoza, J. Luis
Kakutani, Hiroaki
Watatani, Yosaku
Minamoto, Shuji
Taniguchi, Yasuhiro
Nakayama, Shoko
Morita, Yasuyoshi
Ashida, Takashi
Matsumura, Itaru
author_facet Kumode, Takahiro
Rai, Shinya
Tanaka, Hirokazu
Espinoza, J. Luis
Kakutani, Hiroaki
Watatani, Yosaku
Minamoto, Shuji
Taniguchi, Yasuhiro
Nakayama, Shoko
Morita, Yasuyoshi
Ashida, Takashi
Matsumura, Itaru
author_sort Kumode, Takahiro
collection PubMed
description We report a case with extramedullary tumors affecting the supraclavicular region that presented as a relapse of acute myeloid leukemia (AML) with FLT3-ITD mutation after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Treatment with gilteritinib resulted in remarkable response with disappearance of both the medullary and extramedullary tumors. Subsequently, a 2nd allo-HSCT was performed in an attempt to cure his AML and complete molecular response has been sustained with gilteritinib resumption without worsening GVHD. Targeted therapy with gilteritinib for medullary and extramedullary relapse of FLT3-ITD AML could be effective and suitable as a bridging therapy for allo-HSCT.
format Online
Article
Text
id pubmed-7426564
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-74265642020-08-16 Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation Kumode, Takahiro Rai, Shinya Tanaka, Hirokazu Espinoza, J. Luis Kakutani, Hiroaki Watatani, Yosaku Minamoto, Shuji Taniguchi, Yasuhiro Nakayama, Shoko Morita, Yasuyoshi Ashida, Takashi Matsumura, Itaru Leuk Res Rep Article We report a case with extramedullary tumors affecting the supraclavicular region that presented as a relapse of acute myeloid leukemia (AML) with FLT3-ITD mutation after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Treatment with gilteritinib resulted in remarkable response with disappearance of both the medullary and extramedullary tumors. Subsequently, a 2nd allo-HSCT was performed in an attempt to cure his AML and complete molecular response has been sustained with gilteritinib resumption without worsening GVHD. Targeted therapy with gilteritinib for medullary and extramedullary relapse of FLT3-ITD AML could be effective and suitable as a bridging therapy for allo-HSCT. Elsevier 2020-08-07 /pmc/articles/PMC7426564/ /pubmed/32817816 http://dx.doi.org/10.1016/j.lrr.2020.100219 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kumode, Takahiro
Rai, Shinya
Tanaka, Hirokazu
Espinoza, J. Luis
Kakutani, Hiroaki
Watatani, Yosaku
Minamoto, Shuji
Taniguchi, Yasuhiro
Nakayama, Shoko
Morita, Yasuyoshi
Ashida, Takashi
Matsumura, Itaru
Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
title Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
title_full Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
title_fullStr Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
title_full_unstemmed Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
title_short Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
title_sort targeted therapy for medullary and extramedullary relapse of flt3-itd acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426564/
https://www.ncbi.nlm.nih.gov/pubmed/32817816
http://dx.doi.org/10.1016/j.lrr.2020.100219
work_keys_str_mv AT kumodetakahiro targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT raishinya targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT tanakahirokazu targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT espinozajluis targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT kakutanihiroaki targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT watataniyosaku targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT minamotoshuji targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT taniguchiyasuhiro targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT nakayamashoko targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT moritayasuyoshi targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT ashidatakashi targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation
AT matsumuraitaru targetedtherapyformedullaryandextramedullaryrelapseofflt3itdacutemyeloidleukemiafollowingallogeneichematopoieticstemcelltransplantation

Ejemplares similares