A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes

A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit hig...

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Detalles Bibliográficos
Autores principales: Schäfer, Daniel, Henze, Janina, Pfeifer, Rita, Schleicher, Anna, Brauner, Janina, Mockel-Tenbrinck, Nadine, Barth, Carola, Gudert, Daniela, Al Rawashdeh, Wa'el, Johnston, Ian C. D., Hardt, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426717/
https://www.ncbi.nlm.nih.gov/pubmed/32849600
http://dx.doi.org/10.3389/fimmu.2020.01704

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