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Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts

Malassezia includes yeasts belong to the subphylum Ustilaginomycotina within the Basidiomycota. Malassezia yeasts are commonly found as commensals on human and animal skin. Nevertheless, Malassezia species are also associated with several skin disorders, such as dandruff/seborrheic dermatitis, atopi...

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Autores principales: Ianiri, Giuseppe, Heitman, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426719/
https://www.ncbi.nlm.nih.gov/pubmed/32850491
http://dx.doi.org/10.3389/fcimb.2020.00393
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author Ianiri, Giuseppe
Heitman, Joseph
author_facet Ianiri, Giuseppe
Heitman, Joseph
author_sort Ianiri, Giuseppe
collection PubMed
description Malassezia includes yeasts belong to the subphylum Ustilaginomycotina within the Basidiomycota. Malassezia yeasts are commonly found as commensals on human and animal skin. Nevertheless, Malassezia species are also associated with several skin disorders, such as dandruff/seborrheic dermatitis, atopic eczema, pityriasis versicolor, and folliculitis. More recently, associations of Malassezia with Crohn's disease, pancreatic ductal adenocarcinoma, and cystic fibrosis pulmonary exacerbation have been reported. The increasing availability of genomic and molecular tools have played a crucial role in understanding the genetic basis of Malassezia commensalism and pathogenicity. In the present review we report genomics advances in Malassezia highlighting unique features that potentially impacted Malassezia biology and host adaptation. Furthermore, we describe the recently developed protocols for Agrobacterium tumefaciens-mediated transformation in Malassezia, and their applications for random insertional mutagenesis or targeted gene replacement strategies.
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spelling pubmed-74267192020-08-25 Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts Ianiri, Giuseppe Heitman, Joseph Front Cell Infect Microbiol Cellular and Infection Microbiology Malassezia includes yeasts belong to the subphylum Ustilaginomycotina within the Basidiomycota. Malassezia yeasts are commonly found as commensals on human and animal skin. Nevertheless, Malassezia species are also associated with several skin disorders, such as dandruff/seborrheic dermatitis, atopic eczema, pityriasis versicolor, and folliculitis. More recently, associations of Malassezia with Crohn's disease, pancreatic ductal adenocarcinoma, and cystic fibrosis pulmonary exacerbation have been reported. The increasing availability of genomic and molecular tools have played a crucial role in understanding the genetic basis of Malassezia commensalism and pathogenicity. In the present review we report genomics advances in Malassezia highlighting unique features that potentially impacted Malassezia biology and host adaptation. Furthermore, we describe the recently developed protocols for Agrobacterium tumefaciens-mediated transformation in Malassezia, and their applications for random insertional mutagenesis or targeted gene replacement strategies. Frontiers Media S.A. 2020-08-07 /pmc/articles/PMC7426719/ /pubmed/32850491 http://dx.doi.org/10.3389/fcimb.2020.00393 Text en Copyright © 2020 Ianiri and Heitman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Ianiri, Giuseppe
Heitman, Joseph
Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts
title Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts
title_full Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts
title_fullStr Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts
title_full_unstemmed Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts
title_short Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Malassezia Yeasts
title_sort approaches for genetic discoveries in the skin commensal and pathogenic malassezia yeasts
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426719/
https://www.ncbi.nlm.nih.gov/pubmed/32850491
http://dx.doi.org/10.3389/fcimb.2020.00393
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