Melanoma brain metastases: review of histopathological features and immune-molecular aspects

Patients with melanoma brain metastases (MBM) have a dismal prognosis, but the unprecedented advances in systemic therapy alone or in combination with local therapy have now extended the 1-year overall survival rate from 20–25% to nearing 80–85%, mainly in asymptomatic patients. The histopathologica...

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Detalles Bibliográficos
Autores principales: Salvati, Lorenzo, Mandalà, Mario, Massi, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426753/
https://www.ncbi.nlm.nih.gov/pubmed/32821376
http://dx.doi.org/10.2217/mmt-2019-0021
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author Salvati, Lorenzo
Mandalà, Mario
Massi, Daniela
author_facet Salvati, Lorenzo
Mandalà, Mario
Massi, Daniela
author_sort Salvati, Lorenzo
collection PubMed
description Patients with melanoma brain metastases (MBM) have a dismal prognosis, but the unprecedented advances in systemic therapy alone or in combination with local therapy have now extended the 1-year overall survival rate from 20–25% to nearing 80–85%, mainly in asymptomatic patients. The histopathological and molecular characterization of MBM and the understanding of the microenvironment are critical to more effectively manage patients with advanced melanoma and to design biologically driven clinical trials. This review aims to give an overview of the main histopathological features and the immune-molecular aspects of MBM.
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spelling pubmed-74267532020-08-19 Melanoma brain metastases: review of histopathological features and immune-molecular aspects Salvati, Lorenzo Mandalà, Mario Massi, Daniela Melanoma Manag Review Patients with melanoma brain metastases (MBM) have a dismal prognosis, but the unprecedented advances in systemic therapy alone or in combination with local therapy have now extended the 1-year overall survival rate from 20–25% to nearing 80–85%, mainly in asymptomatic patients. The histopathological and molecular characterization of MBM and the understanding of the microenvironment are critical to more effectively manage patients with advanced melanoma and to design biologically driven clinical trials. This review aims to give an overview of the main histopathological features and the immune-molecular aspects of MBM. Future Medicine Ltd 2020-06-08 /pmc/articles/PMC7426753/ /pubmed/32821376 http://dx.doi.org/10.2217/mmt-2019-0021 Text en © 2020 Daniela Massi This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
Salvati, Lorenzo
Mandalà, Mario
Massi, Daniela
Melanoma brain metastases: review of histopathological features and immune-molecular aspects
title Melanoma brain metastases: review of histopathological features and immune-molecular aspects
title_full Melanoma brain metastases: review of histopathological features and immune-molecular aspects
title_fullStr Melanoma brain metastases: review of histopathological features and immune-molecular aspects
title_full_unstemmed Melanoma brain metastases: review of histopathological features and immune-molecular aspects
title_short Melanoma brain metastases: review of histopathological features and immune-molecular aspects
title_sort melanoma brain metastases: review of histopathological features and immune-molecular aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426753/
https://www.ncbi.nlm.nih.gov/pubmed/32821376
http://dx.doi.org/10.2217/mmt-2019-0021
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AT massidaniela melanomabrainmetastasesreviewofhistopathologicalfeaturesandimmunemolecularaspects

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