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Bioorthogonal Ligations and Cleavages in Chemical Biology

Bioorthogonal reactions including the bioorthogonal ligations and cleavages have become an active field of research in chemical biology, and they play important roles in chemical modification and functional regulation of biomolecules. This review summarizes the developments and applications of the r...

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Detalles Bibliográficos
Autores principales: Li, Youshan, Fu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426781/
https://www.ncbi.nlm.nih.gov/pubmed/32817809
http://dx.doi.org/10.1002/open.202000128
Descripción
Sumario:Bioorthogonal reactions including the bioorthogonal ligations and cleavages have become an active field of research in chemical biology, and they play important roles in chemical modification and functional regulation of biomolecules. This review summarizes the developments and applications of the representative bioorthogonal reactions including the Staudinger reactions, the metal‐mediated bioorthogonal reactions, the strain‐promoted cycloadditions, the inverse electron demand Diels‐Alder reactions, the light‐triggered bioorthogonal reactions, and the reactions of chloroquinoxalines and ortho‐dithiophenols.