Cargando…

Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes

Glioblastoma (GBM) is one of the most aggressive types of cancer, which begins within the brain. It is the most invasive type of glioma developed from astrocytes. Until today, Temozolomide (TMZ) is the only standard chemotherapy for patients with GBM. Even though chemotherapy extends the survival of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harmouch, Ezeddine, Seitlinger, Joseph, Chaddad, Hassan, Ubeaud-Sequier, Geneviève, Barths, Jochen, Saidu, Sani, Désaubry, Laurent, Grandemange, Stéphanie, Massfelder, Thierry, Fuhrmann, Guy, Fioretti, Florence, Dontenwill, Monique, Benkirane-Jessel, Nadia, Idoux-Gillet, Ysia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426813/ https://www.ncbi.nlm.nih.gov/pubmed/32792639 http://dx.doi.org/10.1038/s41598-020-70820-6

Ejemplares similares

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1
por: Hassan, Sarah, et al.
Publicado: (2020)

Potential Implantable Nanofibrous Biomaterials Combined with Stem Cells for Subchondral Bone Regeneration
por: Smaida, Rana, et al.
Publicado: (2020)

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
por: Nebigil, Canan G., et al.
Publicado: (2020)

Maxillary Bone Regeneration Based on Nanoreservoirs Functionalized ε-Polycaprolactone Biomembranes in a Mouse Model of Jaw Bone Lesion
por: Strub, Marion, et al.
Publicado: (2018)

Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
por: Keller, Laetitia, et al.
Publicado: (2017)

Patient-Derived Tumoroid for the Prediction of Radiotherapy and Chemotherapy Responses in Non-Small-Cell Lung Cancer
por: Nounsi, Anasse, et al.
Publicado: (2023)

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27
por: Bernard, Yohann, et al.
Publicado: (2011)

Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management
por: Fernandez de Grado, Gabriel, et al.
Publicado: (2018)

Temporomandibular Joint Regenerative Medicine
por: Van Bellinghen, Xavier, et al.
Publicado: (2018)

Application of Chitosan in Bone and Dental Engineering
por: Aguilar, Alicia, et al.
Publicado: (2019)

Vascularization of Patient-Derived Tumoroid from Non-Small-Cell Lung Cancer and Its Microenvironment
por: Seitlinger, Joseph, et al.
Publicado: (2022)

Polymer-Based Instructive Scaffolds for Endodontic Regeneration
por: Zein, Naimah, et al.
Publicado: (2019)

Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
por: Keller, Laetitia, et al.
Publicado: (2019)

In vitro vascularized immunocompetent patient-derived model to test cancer therapies
por: Lê, Hélène, et al.
Publicado: (2023)

Mechanistic Illustration: How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics
por: Bornert, Fabien, et al.
Publicado: (2021)

Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity
por: Blanchard, Maxime G., et al.
Publicado: (2015)

FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity
por: Qureshi, Rehana, et al.
Publicado: (2015)

The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
por: Grindheim, Ann Kari, et al.
Publicado: (2023)

Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects
por: Bentayeb, Hafidha, et al.
Publicado: (2019)

Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies
por: Hsu, Po-Yen, et al.
Publicado: (2021)

Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
por: Yuan, Gangjun, et al.
Publicado: (2018)

Slug Controls Stem/Progenitor Cell Growth Dynamics during Mammary Gland Morphogenesis
por: Nassour, Mayssa, et al.
Publicado: (2012)

Patient-Derived Lung Tumoroids—An Emerging Technology in Drug Development and Precision Medicine
por: Lê, Hélène, et al.
Publicado: (2022)

Correction to: Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
por: Yuan, Gangjun, et al.
Publicado: (2021)

Correction: Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
por: Yuan, Gangjun, et al.
Publicado: (2022)

Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans from Aglaia species (Meliaceae)
por: Greger, Harald
Publicado: (2021)

Endothelial microparticles released by activated protein C protect beta cells through EPCR/PAR1 and annexin A1/FPR2 pathways in islets
por: Kreutter, Guillaume, et al.
Publicado: (2017)

Biomimetic Kinetic Resolution: Highly Enantio- and Diastereoselective Transfer Hydrogenation of Aglain Ketones To Access Flavagline Natural Products
por: Stone, Steven D., et al.
Publicado: (2014)

In silico study on the Hepatitis E virus RNA Helicase and its inhibition by silvestrol, rocaglamide and other flavagline compounds
por: Pedroni, Lorenzo, et al.
Publicado: (2022)

Bone Grafts, Bone Substitutes and Regenerative Medicine Acceptance for the Management of Bone Defects Among French Population: Issues about Ethics, Religion or Fear?
por: Offner, Damien, et al.
Publicado: (2019)

A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration
por: Eap, Sandy, et al.
Publicado: (2015)

Implication of Toll/IL-1 receptor domain containing adapters in Porphyromonas gingivalis-induced inflammation
por: Bugueno, Isaac M, et al.
Publicado: (2021)

Active Nanomaterials to Meet the Challenge of Dental Pulp Regeneration
por: Keller, Laetitia, et al.
Publicado: (2015)

Porphyromonas gingivalis and its lipopolysaccharide differently modulate epidermal growth factor–dependent signaling in human gingival epithelial cells
por: Elkaim, R., et al.
Publicado: (2017)

Temporomandibular joint damage in K/BxN arthritic mice
por: Kuchler-Bopp, Sabine, et al.
Publicado: (2020)

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin
por: Sani, Saidu, et al.
Publicado: (2022)

Cell Type Influences Local Delivery of Biomolecules from a Bioinspired Apatite Drug Delivery System
por: Alhamdi, Jumana, et al.
Publicado: (2018)

Nano-Structured Ridged Micro-Filaments (≥100 µm Diameter) Produced Using a Single Step Strategy for Improved Bone Cell Adhesion and Proliferation in Textile Scaffolds
por: Behary, Nemeshwaree, et al.
Publicado: (2022)

The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways
por: Yang, Xinmei, et al.
Publicado: (2022)

Contribution of Statins towards Periodontal Treatment: A Review
por: Petit, Catherine, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0fv9vnb2n7uc33f5fh539ukhqa