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The gut microbiome in dogs with congestive heart failure: a pilot study
Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426839/ https://www.ncbi.nlm.nih.gov/pubmed/32792610 http://dx.doi.org/10.1038/s41598-020-70826-0 |
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author | Seo, Joonbum Matthewman, Linda Xia, Dong Wilshaw, Jenny Chang, Yu-Mei Connolly, David J. |
author_facet | Seo, Joonbum Matthewman, Linda Xia, Dong Wilshaw, Jenny Chang, Yu-Mei Connolly, David J. |
author_sort | Seo, Joonbum |
collection | PubMed |
description | Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable dysbiosis compared to healthy dogs that are similar in sex and age. A total of 50 dogs (15 healthy dogs and 35 dogs with congestive heart failure) were prospectively recruited, and their faecal gut microbiome was assessed using 16S rRNA sequencing (Illumina MiSeq platform). There was no significant change in the microbial diversity and richness in dogs with congestive heart failure. However, there was an increase in abundance of Proteobacteria in the congestive heart failure group (p = 0.014), particularly due to an increase in the family Enterobacteriaceae (p = 0.002) and Escherichia coli (p = 0.033). We conclude that dogs with congestive heart failure have dysbiosis, and we show additional trends in our data suggesting that dogs may have a similar pattern to that described in people. The results of this study provide useful preliminary information and raise the possibility that dogs represent a clinically relevant animal model of dysbiosis in people with heart failure. |
format | Online Article Text |
id | pubmed-7426839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74268392020-08-14 The gut microbiome in dogs with congestive heart failure: a pilot study Seo, Joonbum Matthewman, Linda Xia, Dong Wilshaw, Jenny Chang, Yu-Mei Connolly, David J. Sci Rep Article Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable dysbiosis compared to healthy dogs that are similar in sex and age. A total of 50 dogs (15 healthy dogs and 35 dogs with congestive heart failure) were prospectively recruited, and their faecal gut microbiome was assessed using 16S rRNA sequencing (Illumina MiSeq platform). There was no significant change in the microbial diversity and richness in dogs with congestive heart failure. However, there was an increase in abundance of Proteobacteria in the congestive heart failure group (p = 0.014), particularly due to an increase in the family Enterobacteriaceae (p = 0.002) and Escherichia coli (p = 0.033). We conclude that dogs with congestive heart failure have dysbiosis, and we show additional trends in our data suggesting that dogs may have a similar pattern to that described in people. The results of this study provide useful preliminary information and raise the possibility that dogs represent a clinically relevant animal model of dysbiosis in people with heart failure. Nature Publishing Group UK 2020-08-13 /pmc/articles/PMC7426839/ /pubmed/32792610 http://dx.doi.org/10.1038/s41598-020-70826-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Seo, Joonbum Matthewman, Linda Xia, Dong Wilshaw, Jenny Chang, Yu-Mei Connolly, David J. The gut microbiome in dogs with congestive heart failure: a pilot study |
title | The gut microbiome in dogs with congestive heart failure: a pilot study |
title_full | The gut microbiome in dogs with congestive heart failure: a pilot study |
title_fullStr | The gut microbiome in dogs with congestive heart failure: a pilot study |
title_full_unstemmed | The gut microbiome in dogs with congestive heart failure: a pilot study |
title_short | The gut microbiome in dogs with congestive heart failure: a pilot study |
title_sort | gut microbiome in dogs with congestive heart failure: a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426839/ https://www.ncbi.nlm.nih.gov/pubmed/32792610 http://dx.doi.org/10.1038/s41598-020-70826-0 |
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