Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

Although metastasis is the most common cause of cancer deaths, metastasis-intrinsic dependencies remain largely uncharacterized. We previously reported that metastatic pancreatic cancers were dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Surprisingly, PGD catalys...

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Detalles Bibliográficos
Autores principales: Bechard, Matthew E., Smalling, Rana, Hayashi, Akimasa, Zhong, Yi, Word, Anna E., Campbell, Sydney L., Tran, Amanda V., Weiss, Vivian L., Iacobuzio-Donahue, Christine, Wellen, Kathryn E., McDonald, Oliver G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426874/
https://www.ncbi.nlm.nih.gov/pubmed/32792504
http://dx.doi.org/10.1038/s41467-020-17839-5

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