Induction of mitochondria-mediated apoptosis and suppression of tumor growth in zebrafish xenograft model by cyclic dipeptides identified from Exiguobacterium acetylicum

Colorectal cancer is the most common type of gastrointestinal cancers with poor survival and limited therapeutic options. In this study, four structurally different cyclic dipeptides (or diketopiperazine) were isolated and identified as cyclo (l-Pro-l-Leu), cyclo (l-Pro-l-Val), cyclo (l-Pro-l-Phe) a...

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Detalles Bibliográficos
Autores principales: Jinendiran, Sekar, Teng, Weilin, Dahms, Hans-Uwe, Liu, Wangta, Ponnusamy, Vinoth Kumar, Chiu, Charles Chien-Chih, Kumar, B. S. Dileep, Sivakumar, Natesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426938/
https://www.ncbi.nlm.nih.gov/pubmed/32792514
http://dx.doi.org/10.1038/s41598-020-70516-x

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