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High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature

Rhabdomyosarcoma is an aggressive malignant soft-tissue sarcoma that develop from undifferentiated mesenchymal cells. Less than 1% of all adult solid malignant cancers are sarcomas, and RMSs represent less than 2–5% of adult sarcomas.   RMS is divided into three main subtypes: Embryonal, alveolar an...

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Autores principales: Taza, Fadi, Kanwal, Arjun, Zulty, Mary, Mustafa, Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426990/
https://www.ncbi.nlm.nih.gov/pubmed/32850081
http://dx.doi.org/10.1080/20009666.2020.1766820
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author Taza, Fadi
Kanwal, Arjun
Zulty, Mary
Mustafa, Sadaf
author_facet Taza, Fadi
Kanwal, Arjun
Zulty, Mary
Mustafa, Sadaf
author_sort Taza, Fadi
collection PubMed
description Rhabdomyosarcoma is an aggressive malignant soft-tissue sarcoma that develop from undifferentiated mesenchymal cells. Less than 1% of all adult solid malignant cancers are sarcomas, and RMSs represent less than 2–5% of adult sarcomas.   RMS is divided into three main subtypes: Embryonal, alveolar and pleomorphic RMS (PRMS).   Most common subtype in adults is PRMS. Most common primary sites are extremities, trunk wall, and genitourinary organs. Metastasis are often found at diagnosis. 5-year overall survival rates were reported in the Surveillance, Epidemiology, and End Results database (SEER) to be 63% for pediatric patients and 27% for adults. Given the rarity of the adult PRMS, variation in its clinical presentation, characteristics of the tumor itself and the prognosis; there are very limited data available to guide the management of adults with PRMS. Herein we present a case report of pleomorphic rhabdomyosarcoma of the right thigh in a 60-year-old male who achieved a long-term survival (30 months) which was accomplished by multimodality treatment including surgery, radiotherapy, and chemotherapy.   
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spelling pubmed-74269902020-08-25 High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature Taza, Fadi Kanwal, Arjun Zulty, Mary Mustafa, Sadaf J Community Hosp Intern Med Perspect Case Report Rhabdomyosarcoma is an aggressive malignant soft-tissue sarcoma that develop from undifferentiated mesenchymal cells. Less than 1% of all adult solid malignant cancers are sarcomas, and RMSs represent less than 2–5% of adult sarcomas.   RMS is divided into three main subtypes: Embryonal, alveolar and pleomorphic RMS (PRMS).   Most common subtype in adults is PRMS. Most common primary sites are extremities, trunk wall, and genitourinary organs. Metastasis are often found at diagnosis. 5-year overall survival rates were reported in the Surveillance, Epidemiology, and End Results database (SEER) to be 63% for pediatric patients and 27% for adults. Given the rarity of the adult PRMS, variation in its clinical presentation, characteristics of the tumor itself and the prognosis; there are very limited data available to guide the management of adults with PRMS. Herein we present a case report of pleomorphic rhabdomyosarcoma of the right thigh in a 60-year-old male who achieved a long-term survival (30 months) which was accomplished by multimodality treatment including surgery, radiotherapy, and chemotherapy.    Taylor & Francis 2020-06-14 /pmc/articles/PMC7426990/ /pubmed/32850081 http://dx.doi.org/10.1080/20009666.2020.1766820 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Taza, Fadi
Kanwal, Arjun
Zulty, Mary
Mustafa, Sadaf
High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature
title High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature
title_full High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature
title_fullStr High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature
title_full_unstemmed High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature
title_short High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature
title_sort high-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426990/
https://www.ncbi.nlm.nih.gov/pubmed/32850081
http://dx.doi.org/10.1080/20009666.2020.1766820
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