Nicotinamide riboside with pterostilbene (NRPT) increases NAD(+) in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

BACKGROUND: Preclinical studies have identified both NAD(+) and sirtuin augmentation as potential strategies for the prevention and treatment of AKI. Nicotinamide riboside (NR) is a NAD(+) precursor vitamin and pterostilbene (PT) is potent sirtuin activator found in blueberries. Here, we tested the...

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Detalles Bibliográficos
Autores principales: Simic, Petra, Vela Parada, Xavier Fernando, Parikh, Samir M., Dellinger, Ryan, Guarente, Leonard P., Rhee, Eugene P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427083/
https://www.ncbi.nlm.nih.gov/pubmed/32791973
http://dx.doi.org/10.1186/s12882-020-02006-1

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