Cargando…

New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice

Cyclic dinucleotides (CDNs) are promising vaccine adjuvants inducing balanced, potent humoral, and cellular immune responses. How aging influences CDN efficacy is unclear. We examined the vaccine efficacy of 3′,5′-cyclic diguanylic acid (cyclic di-GMP, CDG), the founding member of CDNs, in 1-year-ol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gogoi, Himanshu, Mansouri, Samira, Katikaneni, Divya S., Jin, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427090/ https://www.ncbi.nlm.nih.gov/pubmed/32849581 http://dx.doi.org/10.3389/fimmu.2020.01674

Ejemplares similares

Immature lung TNFR2(−) conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo
por: Mansouri, Samira, et al.
Publicado: (2018)

The Age of Cyclic Dinucleotide Vaccine Adjuvants
por: Gogoi, Himanshu, et al.
Publicado: (2020)

Lung IFNAR1(hi) TNFR2(+) cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state
por: Mansouri, Samira, et al.
Publicado: (2020)

Decreased antigen-specific T-cell proliferation by moDC among hepatitis B vaccine non-responders on haemodialysis
por: Verkade, M. A., et al.
Publicado: (2007)

STAT Family Protein Expression and Phosphorylation State during moDC Development Is Altered by Platinum-Based Chemotherapeutics
por: de Haas, Nienke, et al.
Publicado: (2019)

The Role of Porcine Monocyte Derived Dendritic Cells (MoDC) in the Inflammation Storm Caused by Streptococcus suis Serotype 2 Infection
por: Liu, Jin, et al.
Publicado: (2016)

Specific Polyunsaturated Fatty Acids Can Modulate in vitro Human moDC2s and Subsequent Th2 Cytokine Release
por: Hoppenbrouwers, Tamara, et al.
Publicado: (2020)

Tailored PGE2 Immunomodulation of moDCs by Nano-Encapsulated EP2/EP4 Antagonists
por: Bödder, Johanna, et al.
Publicado: (2023)

Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83
por: Gong, Xingyu, et al.
Publicado: (2023)

The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo
por: Blaauboer, Steven M, et al.
Publicado: (2015)

Nitric oxide regulated cyclic di-GMP signaling
por: Boon, Elizabeth M, et al.
Publicado: (2013)

Cyclic di-GMP signalling and the regulation of bacterial virulence
por: Ryan, Robert P.
Publicado: (2013)

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas aeruginosa and Other Bacteria
por: Valentini, Martina, et al.
Publicado: (2016)

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP
por: Onyedibe, Kenneth I., et al.
Publicado: (2021)

Mechanism of activation of bacterial cellulose synthase by cyclic-di-GMP
por: Morgan, Jacob L. W., et al.
Publicado: (2014)

Cyclic di-GMP regulates Mycobacterium tuberculosis resistance to ethionamide
por: Zhang, Hai-Nan, et al.
Publicado: (2017)

Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches
por: Keller, Heiko, et al.
Publicado: (2018)

Adjuvants and adjuvanticity
por: Tizard, Ian R.
Publicado: (2021)

A cyclic-di-GMP receptor required for bacterial exopolysaccharide production
por: Lee, Vincent T, et al.
Publicado: (2007)

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks
por: He, Ming, et al.
Publicado: (2011)

STING is a direct innate immune sensor of cyclic-di-GMP
por: Burdette, Dara L., et al.
Publicado: (2011)

Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia
por: Richter, Anja M., et al.
Publicado: (2019)

Sensing the Messenger: Potential Roles of Cyclic-di-GMP in Rickettsial Pathogenesis
por: Narra, Hema P., et al.
Publicado: (2022)

Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP
por: Schumacher, Maria A., et al.
Publicado: (2022)

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems
por: Roelofs, Kevin G., et al.
Publicado: (2015)

Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa
por: Ruksakiet, Kasidid, et al.
Publicado: (2021)

Double take: A dual-functional Hypr GGDEF synthesizes both cyclic di-GMP and cyclic GMP—AMP to control predation in Bdellovibrio bacteriovorus
por: Rangarajan, Aathmaja Anandhi, et al.
Publicado: (2022)

Cyclic di-GMP-dependent Signaling Pathways in the Pathogenic Firmicute Listeria monocytogenes
por: Chen, Li-Hong, et al.
Publicado: (2014)

Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective
por: Agostoni, Marco, et al.
Publicado: (2013)

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi
por: Novak, Elizabeth A., et al.
Publicado: (2014)

Physiological and Microscopic Characterization of Cyclic-di-GMP-Mediated Autoaggregation in Erwinia amylovora
por: Kharadi, Roshni R., et al.
Publicado: (2019)

Hybrid histidine kinase activation by cyclic di-GMP–mediated domain liberation
por: Dubey, Badri N., et al.
Publicado: (2020)

Control of light-dependent behaviour in cyanobacteria by the second messenger cyclic di-GMP
por: Enomoto, Gen, et al.
Publicado: (2023)

CRP-Cyclic AMP Regulates the Expression of Type 3 Fimbriae via Cyclic di-GMP in Klebsiella pneumoniae
por: Lin, Ching-Ting, et al.
Publicado: (2016)

Secreted Cyclic Di-GMP Induces Stalk Cell Differentiation in the Eukaryote Dictyostelium discoideum
por: Chen, Zhi-hui, et al.
Publicado: (2015)

Cyclic Di-GMP Regulates Type IV Pilus-Dependent Motility in Myxococcus xanthus
por: Skotnicka, Dorota, et al.
Publicado: (2015)

Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion
por: McCarthy, Ronan R., et al.
Publicado: (2017)

Cyclic di‐GMP inactivates T6SS and T4SS activity in Agrobacterium tumefaciens
por: McCarthy, Ronan R., et al.
Publicado: (2019)

Evolution of cyclic di-GMP signalling on a short and long term time scale
por: Römling, Ute, et al.
Publicado: (2023)

DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
por: Parvatiyar, Kislay, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1utcnsrprlagfrd6vri62ia28h