Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020

Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable vir...

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Autores principales: Singanayagam, Anika, Patel, Monika, Charlett, Andre, Lopez Bernal, Jamie, Saliba, Vanessa, Ellis, Joanna, Ladhani, Shamez, Zambon, Maria, Gopal, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427302/
https://www.ncbi.nlm.nih.gov/pubmed/32794447
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.32.2001483
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author Singanayagam, Anika
Patel, Monika
Charlett, Andre
Lopez Bernal, Jamie
Saliba, Vanessa
Ellis, Joanna
Ladhani, Shamez
Zambon, Maria
Gopal, Robin
author_facet Singanayagam, Anika
Patel, Monika
Charlett, Andre
Lopez Bernal, Jamie
Saliba, Vanessa
Ellis, Joanna
Ladhani, Shamez
Zambon, Maria
Gopal, Robin
author_sort Singanayagam, Anika
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.
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spelling pubmed-74273022020-08-24 Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020 Singanayagam, Anika Patel, Monika Charlett, Andre Lopez Bernal, Jamie Saliba, Vanessa Ellis, Joanna Ladhani, Shamez Zambon, Maria Gopal, Robin Euro Surveill Rapid Communication Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus. European Centre for Disease Prevention and Control (ECDC) 2020-08-13 /pmc/articles/PMC7427302/ /pubmed/32794447 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.32.2001483 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Singanayagam, Anika
Patel, Monika
Charlett, Andre
Lopez Bernal, Jamie
Saliba, Vanessa
Ellis, Joanna
Ladhani, Shamez
Zambon, Maria
Gopal, Robin
Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
title Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
title_full Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
title_fullStr Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
title_full_unstemmed Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
title_short Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
title_sort duration of infectiousness and correlation with rt-pcr cycle threshold values in cases of covid-19, england, january to may 2020
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427302/
https://www.ncbi.nlm.nih.gov/pubmed/32794447
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.32.2001483
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