Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

It is widely assumed that decreasing transcription factor DNA-binding affinity reduces transcription initiation by diminishing occupancy of sequence-specific regulatory elements. However, in vivo transcription factors find their binding sites while confronted with a large excess of low-affinity dege...

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Detalles Bibliográficos
Autores principales: Louphrasitthiphol, Pakavarin, Siddaway, Robert, Loffreda, Alessia, Pogenberg, Vivian, Friedrichsen, Hans, Schepsky, Alexander, Zeng, Zhiqiang, Lu, Min, Strub, Thomas, Freter, Rasmus, Lisle, Richard, Suer, Eda, Thomas, Benjamin, Schuster-Böckler, Benjamin, Filippakopoulos, Panagis, Middleton, Mark, Lu, Xin, Patton, E. Elizabeth, Davidson, Irwin, Lambert, Jean-Philippe, Wilmanns, Matthias, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427332/
https://www.ncbi.nlm.nih.gov/pubmed/32531202
http://dx.doi.org/10.1016/j.molcel.2020.05.025

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