1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea Protects the Blood-Brain Barrier Against Ischemic Injury by Upregulating Tight Junction Protein Expression, Mitigating Apoptosis and Inflammation In Vivo and In Vitro Model

We previously have revealed that 1-trifluoromethoxyphenyl-3-(1- propionylpiperidin-4-yl) urea (TPPU), as a soluble epoxide hydrolase (sEH) inhibitor can reduce infarct volume, protect blood-brain barrier (BBB) and brain against ischemic injury in rats. Here, we investigated the potential mechanisms...

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Detalles Bibliográficos
Autores principales: Yi, Xingyang, Xu, Chongxi, Huang, Pan, Zhang, Linlei, Qing, Ting, Li, Jie, Wang, Chun, Zeng, Tao, Lu, Jing, Han, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427473/
https://www.ncbi.nlm.nih.gov/pubmed/32848796
http://dx.doi.org/10.3389/fphar.2020.01197

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