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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute...

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Detalles Bibliográficos
Autores principales: Sekine, Takuya, Perez-Potti, André, Rivera-Ballesteros, Olga, Strålin, Kristoffer, Gorin, Jean-Baptiste, Olsson, Annika, Llewellyn-Lacey, Sian, Kamal, Habiba, Bogdanovic, Gordana, Muschiol, Sandra, Wullimann, David J., Kammann, Tobias, Emgård, Johanna, Parrot, Tiphaine, Folkesson, Elin, Rooyackers, Olav, Eriksson, Lars I., Henter, Jan-Inge, Sönnerborg, Anders, Allander, Tobias, Albert, Jan, Nielsen, Morten, Klingström, Jonas, Gredmark-Russ, Sara, Björkström, Niklas K., Sandberg, Johan K., Price, David A., Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427556/
https://www.ncbi.nlm.nih.gov/pubmed/32979941
http://dx.doi.org/10.1016/j.cell.2020.08.017
Descripción
Sumario:SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.