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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute...

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Autores principales: Sekine, Takuya, Perez-Potti, André, Rivera-Ballesteros, Olga, Strålin, Kristoffer, Gorin, Jean-Baptiste, Olsson, Annika, Llewellyn-Lacey, Sian, Kamal, Habiba, Bogdanovic, Gordana, Muschiol, Sandra, Wullimann, David J., Kammann, Tobias, Emgård, Johanna, Parrot, Tiphaine, Folkesson, Elin, Rooyackers, Olav, Eriksson, Lars I., Henter, Jan-Inge, Sönnerborg, Anders, Allander, Tobias, Albert, Jan, Nielsen, Morten, Klingström, Jonas, Gredmark-Russ, Sara, Björkström, Niklas K., Sandberg, Johan K., Price, David A., Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427556/
https://www.ncbi.nlm.nih.gov/pubmed/32979941
http://dx.doi.org/10.1016/j.cell.2020.08.017
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author Sekine, Takuya
Perez-Potti, André
Rivera-Ballesteros, Olga
Strålin, Kristoffer
Gorin, Jean-Baptiste
Olsson, Annika
Llewellyn-Lacey, Sian
Kamal, Habiba
Bogdanovic, Gordana
Muschiol, Sandra
Wullimann, David J.
Kammann, Tobias
Emgård, Johanna
Parrot, Tiphaine
Folkesson, Elin
Rooyackers, Olav
Eriksson, Lars I.
Henter, Jan-Inge
Sönnerborg, Anders
Allander, Tobias
Albert, Jan
Nielsen, Morten
Klingström, Jonas
Gredmark-Russ, Sara
Björkström, Niklas K.
Sandberg, Johan K.
Price, David A.
Ljunggren, Hans-Gustaf
Aleman, Soo
Buggert, Marcus
author_facet Sekine, Takuya
Perez-Potti, André
Rivera-Ballesteros, Olga
Strålin, Kristoffer
Gorin, Jean-Baptiste
Olsson, Annika
Llewellyn-Lacey, Sian
Kamal, Habiba
Bogdanovic, Gordana
Muschiol, Sandra
Wullimann, David J.
Kammann, Tobias
Emgård, Johanna
Parrot, Tiphaine
Folkesson, Elin
Rooyackers, Olav
Eriksson, Lars I.
Henter, Jan-Inge
Sönnerborg, Anders
Allander, Tobias
Albert, Jan
Nielsen, Morten
Klingström, Jonas
Gredmark-Russ, Sara
Björkström, Niklas K.
Sandberg, Johan K.
Price, David A.
Ljunggren, Hans-Gustaf
Aleman, Soo
Buggert, Marcus
author_sort Sekine, Takuya
collection PubMed
description SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
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spelling pubmed-74275562020-08-14 Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 Sekine, Takuya Perez-Potti, André Rivera-Ballesteros, Olga Strålin, Kristoffer Gorin, Jean-Baptiste Olsson, Annika Llewellyn-Lacey, Sian Kamal, Habiba Bogdanovic, Gordana Muschiol, Sandra Wullimann, David J. Kammann, Tobias Emgård, Johanna Parrot, Tiphaine Folkesson, Elin Rooyackers, Olav Eriksson, Lars I. Henter, Jan-Inge Sönnerborg, Anders Allander, Tobias Albert, Jan Nielsen, Morten Klingström, Jonas Gredmark-Russ, Sara Björkström, Niklas K. Sandberg, Johan K. Price, David A. Ljunggren, Hans-Gustaf Aleman, Soo Buggert, Marcus Cell Article SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. The Author(s). Published by Elsevier Inc. 2020-10-01 2020-08-14 /pmc/articles/PMC7427556/ /pubmed/32979941 http://dx.doi.org/10.1016/j.cell.2020.08.017 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sekine, Takuya
Perez-Potti, André
Rivera-Ballesteros, Olga
Strålin, Kristoffer
Gorin, Jean-Baptiste
Olsson, Annika
Llewellyn-Lacey, Sian
Kamal, Habiba
Bogdanovic, Gordana
Muschiol, Sandra
Wullimann, David J.
Kammann, Tobias
Emgård, Johanna
Parrot, Tiphaine
Folkesson, Elin
Rooyackers, Olav
Eriksson, Lars I.
Henter, Jan-Inge
Sönnerborg, Anders
Allander, Tobias
Albert, Jan
Nielsen, Morten
Klingström, Jonas
Gredmark-Russ, Sara
Björkström, Niklas K.
Sandberg, Johan K.
Price, David A.
Ljunggren, Hans-Gustaf
Aleman, Soo
Buggert, Marcus
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_full Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_fullStr Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_full_unstemmed Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_short Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_sort robust t cell immunity in convalescent individuals with asymptomatic or mild covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427556/
https://www.ncbi.nlm.nih.gov/pubmed/32979941
http://dx.doi.org/10.1016/j.cell.2020.08.017
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