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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and enhancers remain enigmatic. Here, we demonstrate that Integrator subunit 11 (INTS11), the catalytic subunit of the Integrator complex, regulates transcript...

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Detalles Bibliográficos
Autores principales:	Beckedorff, Felipe, Blumenthal, Ezra, daSilva, Lucas Ferreira, Aoi, Yuki, Cingaram, Pradeep Reddy, Yue, Jingyin, Zhang, Anda, Dokaneheifard, Sadat, Valencia, Monica Guiselle, Gaidosh, Gabriel, Shilatifard, Ali, Shiekhattar, Ramin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427568/ https://www.ncbi.nlm.nih.gov/pubmed/32697989 http://dx.doi.org/10.1016/j.celrep.2020.107917

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