The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology

Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular deter...

Descripción completa

Detalles Bibliográficos
Autores principales: Liao, Yajin, Dong, Yuan, Cheng, Jinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427582/
https://www.ncbi.nlm.nih.gov/pubmed/32848610
http://dx.doi.org/10.3389/fncel.2020.00194
_version_ 1783570905206620160
author Liao, Yajin
Dong, Yuan
Cheng, Jinbo
author_facet Liao, Yajin
Dong, Yuan
Cheng, Jinbo
author_sort Liao, Yajin
collection PubMed
description Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediate the membrane contact between mitochondria and other organelles, and their functions, have been revealed in recent years. In this review article, we aim to summarize the findings on the tethering between mitochondria and other organelles in physiological or pathological conditions, and discuss their roles in cellular homeostasis, neural activity, and neurodegenerative diseases.
format Online
Article
Text
id pubmed-7427582
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74275822020-08-25 The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology Liao, Yajin Dong, Yuan Cheng, Jinbo Front Cell Neurosci Cellular Neuroscience Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediate the membrane contact between mitochondria and other organelles, and their functions, have been revealed in recent years. In this review article, we aim to summarize the findings on the tethering between mitochondria and other organelles in physiological or pathological conditions, and discuss their roles in cellular homeostasis, neural activity, and neurodegenerative diseases. Frontiers Media S.A. 2020-08-07 /pmc/articles/PMC7427582/ /pubmed/32848610 http://dx.doi.org/10.3389/fncel.2020.00194 Text en Copyright © 2020 Liao, Dong and Cheng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Liao, Yajin
Dong, Yuan
Cheng, Jinbo
The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology
title The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology
title_full The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology
title_fullStr The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology
title_full_unstemmed The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology
title_short The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology
title_sort molecular determinants of mitochondrial membrane contact with er, lysosomes and peroxisomes in neuronal physiology and pathology
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427582/
https://www.ncbi.nlm.nih.gov/pubmed/32848610
http://dx.doi.org/10.3389/fncel.2020.00194
work_keys_str_mv AT liaoyajin themoleculardeterminantsofmitochondrialmembranecontactwitherlysosomesandperoxisomesinneuronalphysiologyandpathology
AT dongyuan themoleculardeterminantsofmitochondrialmembranecontactwitherlysosomesandperoxisomesinneuronalphysiologyandpathology
AT chengjinbo themoleculardeterminantsofmitochondrialmembranecontactwitherlysosomesandperoxisomesinneuronalphysiologyandpathology
AT liaoyajin moleculardeterminantsofmitochondrialmembranecontactwitherlysosomesandperoxisomesinneuronalphysiologyandpathology
AT dongyuan moleculardeterminantsofmitochondrialmembranecontactwitherlysosomesandperoxisomesinneuronalphysiologyandpathology
AT chengjinbo moleculardeterminantsofmitochondrialmembranecontactwitherlysosomesandperoxisomesinneuronalphysiologyandpathology

Ejemplares similares