Anca negative pauci-immune crescentic glomerulonephritis and mixed connective tissue disease: a case study

One of the most common causes of rapidly progressive glomerulonephritis (RPGN) is pauci-immune crescentic glomerulonephritis (CrGN). In the majority of cases, this condition has a positive serologic marker, the anti-neutrophil cytoplasmic antibodies (ANCAs), but in approximately 10% there are no cir...

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Detalles Bibliográficos
Autores principales: Fernandes, Sara, Teixeira, Catarina, Falcão, Luis Pedro, Costa, Ana Cortesão, Raimundo, Mário, Silva, Sónia, Cardoso, João, Almeida, Edgar De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Nefrologia 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427652/
https://www.ncbi.nlm.nih.gov/pubmed/30897193
http://dx.doi.org/10.1590/2175-8239-JBN-2019-0003
Descripción
Sumario:One of the most common causes of rapidly progressive glomerulonephritis (RPGN) is pauci-immune crescentic glomerulonephritis (CrGN). In the majority of cases, this condition has a positive serologic marker, the anti-neutrophil cytoplasmic antibodies (ANCAs), but in approximately 10% there are no circulating ANCAs, and this subgroup has been known as the ANCA-negative pauci-immune CrGN. RPGN can be associated with systemic diseases, but there are only few case reports describing the association with mixed connective tissue disease (MCTD). The authors report a case of ANCA-negative CrGN associated with a MCTD.

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