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Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification

In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis (para-X phenyl)porphyrinato M (II) [where X = H, NH(2) and COOMe for M = Cu and X = COOH  and OMe for M = Co]. The activity study of the as-synthesized metalloporphyrins toward two Gram-positive (S. aureus a...

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Autores principales: Beyene, Belete B., Wassie, Getaneh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427740/
https://www.ncbi.nlm.nih.gov/pubmed/32818202
http://dx.doi.org/10.1186/s13065-020-00701-6
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author Beyene, Belete B.
Wassie, Getaneh A.
author_facet Beyene, Belete B.
Wassie, Getaneh A.
author_sort Beyene, Belete B.
collection PubMed
description In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis (para-X phenyl)porphyrinato M (II) [where X = H, NH(2) and COOMe for M = Cu and X = COOH  and OMe for M = Co]. The activity study of the as-synthesized metalloporphyrins toward two Gram-positive (S. aureus and S. pyogenes) and two Gram-negative (E. coli and K. pneumoniae) bacteria showed a promising inhibitory activity. Among the complexes under study, the highest antibacterial activity is observed for 5, 10, 15, 20-tetrakis (p-carboxyphenyl)porphyrinato cobalt (II), with inhibition zone of 16.5 mm against Staphylococcus aureus (S. aureus). This activity could be attributed to the high binding ability of COOH group to cellular components, membranes, proteins, and DNA as well as the lipophilicity of the complex. Moreover, consistent with literature report, the study revealed that metalloporphyrins with electron withdrawing group at para-positions have better antibacterial activity than metalloporphyrin which possess electron donating group at para position.
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spelling pubmed-74277402020-08-17 Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification Beyene, Belete B. Wassie, Getaneh A. BMC Chem Research Article In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis (para-X phenyl)porphyrinato M (II) [where X = H, NH(2) and COOMe for M = Cu and X = COOH  and OMe for M = Co]. The activity study of the as-synthesized metalloporphyrins toward two Gram-positive (S. aureus and S. pyogenes) and two Gram-negative (E. coli and K. pneumoniae) bacteria showed a promising inhibitory activity. Among the complexes under study, the highest antibacterial activity is observed for 5, 10, 15, 20-tetrakis (p-carboxyphenyl)porphyrinato cobalt (II), with inhibition zone of 16.5 mm against Staphylococcus aureus (S. aureus). This activity could be attributed to the high binding ability of COOH group to cellular components, membranes, proteins, and DNA as well as the lipophilicity of the complex. Moreover, consistent with literature report, the study revealed that metalloporphyrins with electron withdrawing group at para-positions have better antibacterial activity than metalloporphyrin which possess electron donating group at para position. Springer International Publishing 2020-08-14 /pmc/articles/PMC7427740/ /pubmed/32818202 http://dx.doi.org/10.1186/s13065-020-00701-6 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Beyene, Belete B.
Wassie, Getaneh A.
Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification
title Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification
title_full Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification
title_fullStr Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification
title_full_unstemmed Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification
title_short Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification
title_sort antibacterial activity of cu(ii) and co(ii) porphyrins: role of ligand modification
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427740/
https://www.ncbi.nlm.nih.gov/pubmed/32818202
http://dx.doi.org/10.1186/s13065-020-00701-6
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