Cargando…

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

BACKGROUND: Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and lipoprotein binding receptor expressed by cells of myeloid origin. Homozygous TREM2 mutations cause early onset progressive presenile dementia while heterozygous, point mutations triple the risk of Alzheimer’s disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Price, Brittani R., Sudduth, Tiffany L., Weekman, Erica M., Johnson, Sherika, Hawthorne, Danielle, Woolums, Abigail, Wilcock, Donna M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427742/ https://www.ncbi.nlm.nih.gov/pubmed/32795308 http://dx.doi.org/10.1186/s12974-020-01915-0

Ejemplares similares

Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events
por: Weekman, Erica M., et al.
Publicado: (2019)

β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice
por: Sudduth, Tiffany L, et al.
Publicado: (2014)

Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice
por: Weekman, Erica M, et al.
Publicado: (2014)

Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain
por: Weekman, Erica M., et al.
Publicado: (2017)

Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype
por: Sudduth, Tiffany L., et al.
Publicado: (2012)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET
por: Oh, Se Jong, et al.
Publicado: (2018)

Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia
por: Price, Brittani R., et al.
Publicado: (2018)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
por: Tsui, Ka Chun, et al.
Publicado: (2022)

Plasma amyloid beta levels are associated with cerebral amyloid and tau deposition
por: Risacher, Shannon L., et al.
Publicado: (2019)

Serum albumin and beta-amyloid deposition in the human brain
por: Kim, Jee Wook, et al.
Publicado: (2020)

Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina
por: Barton, Shawn M., et al.
Publicado: (2021)

Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice
por: Mei, Zhen, et al.
Publicado: (2023)

Peritubular and Perivascular Amyloid Deposits in Amyloid Nephropathy
por: Chiba, Yuki, et al.
Publicado: (2021)

Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
por: Weekman, Erica M., et al.
Publicado: (2023)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
por: Zhao, Peng, et al.
Publicado: (2022)

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease
por: Melzer, Tracy R., et al.
Publicado: (2019)

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice
por: Latta, Clare H, et al.
Publicado: (2015)

HEARING IMPAIRMENT, COGNITIVE PERFORMANCE, AND BETA-AMYLOID DEPOSITION IN THE ARIC-PET AMYLOID IMAGING STUDY
por: Deal, Jennifer A, et al.
Publicado: (2019)

Positron emission tomography imaging of amyloid-beta plaque deposition: a decade of translation
por: Price, Julie C, et al.
Publicado: (2012)

TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer’s Disease
por: La Rosa, Francesca, et al.
Publicado: (2023)

Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Bowers, Zackary, et al.
Publicado: (2021)

Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease risk
por: Salih, Dervis A, et al.
Publicado: (2019)

Age-related and amyloid-beta-independent tau deposition and its downstream effects
por: Wuestefeld, Anika, et al.
Publicado: (2023)

Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract
por: Chao, Chien-Liang, et al.
Publicado: (2019)

Vestibular Function and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging
por: Kamil, Rebecca J., et al.
Publicado: (2018)

Serum zinc levels and in vivo beta-amyloid deposition in the human brain
por: Kim, Jee Wook, et al.
Publicado: (2021)

Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer’s Disease
por: Baek, Min Seok, et al.
Publicado: (2022)

Sensory Impairment and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging
por: Armstrong, Nicole, et al.
Publicado: (2021)

Sensory impairment and beta‐amyloid deposition in the Baltimore longitudinal study of aging
por: Yesantharao, Lekha, et al.
Publicado: (2023)

Does statin use affect amyloid beta deposition and brain metabolism?
por: Nabizadeh, Fardin, et al.
Publicado: (2023)

What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?
por: Friedland, Robert P., et al.
Publicado: (2020)

In vivo staging of regional amyloid deposition
por: Grothe, Michel J., et al.
Publicado: (2017)

On the Nature of the Waxy, Lardaceous, or Amyloid Deposit
por: Dickinson, William H.
Publicado: (1868)

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients
por: Dinkel, Felix, et al.
Publicado: (2020)

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
por: Wilcock, Donna M, et al.
Publicado: (2004)

Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice
por: Hosokawa, Masato, et al.
Publicado: (2017)

Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging
por: Kim, Chan‐Mi, et al.
Publicado: (2021)

Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression
por: Nho, Kwangsik, et al.
Publicado: (2021)

VIP Enhances Phagocytosis of Fibrillar Beta-Amyloid by Microglia and Attenuates Amyloid Deposition in the Brain of APP/PS1 Mice
por: Song, Min, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_0bl0rbc7u6h98sbhniutn6c08d