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WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control

BACKGROUND: Asthma is one of the most common chronic diseases in childhood. Regular follow-up of physiological parameters in the home setting, in relation to asthma symptoms, can provide complementary quantitative insights into the dynamics of the asthma status. Despite considerable interest in asth...

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Autores principales: van der Kamp, M. R., Klaver, E. C., Thio, B. J., Driessen, J. M. M., de Jongh, F. H. C., Tabak, M., van der Palen, J., Hermens, H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427745/
https://www.ncbi.nlm.nih.gov/pubmed/32795352
http://dx.doi.org/10.1186/s12911-020-01210-1
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author van der Kamp, M. R.
Klaver, E. C.
Thio, B. J.
Driessen, J. M. M.
de Jongh, F. H. C.
Tabak, M.
van der Palen, J.
Hermens, H. J.
author_facet van der Kamp, M. R.
Klaver, E. C.
Thio, B. J.
Driessen, J. M. M.
de Jongh, F. H. C.
Tabak, M.
van der Palen, J.
Hermens, H. J.
author_sort van der Kamp, M. R.
collection PubMed
description BACKGROUND: Asthma is one of the most common chronic diseases in childhood. Regular follow-up of physiological parameters in the home setting, in relation to asthma symptoms, can provide complementary quantitative insights into the dynamics of the asthma status. Despite considerable interest in asthma home-monitoring in children, there is a paucity of scientific evidence, especially on multi-parameter monitoring approaches. Therefore, the aim of this study is to investigate whether asthma control can be accurately assessed in the home situation by combining parameters from respiratory physiology sensors. METHODS: Sixty asthmatic and thirty non-asthmatic children were enrolled in the observational WEARCON-study. Asthma control was assessed according to GINA guidelines by the paediatrician. All children were also evaluated during a 2-week home-monitoring period with wearable devices; a physical activity tracker, a handheld spirometer, smart inhalers, and an ambulatory electrocardiography device to monitor heart and respiratory rate. Multiple logistic regression analysis was used to determine which diagnostic measures were associated with asthma control. RESULTS: 24 of the 27 uncontrolled asthmatic children and 29 of the 32 controlled asthmatic children could be accurately identified with this model. The final model showed that a larger variation in pre-exercise lung function (OR = 1.34 95%-CI 1.07–1.68), an earlier wake-up-time (OR = 1.05 95%-CI 1.01–1.10), more reliever use (OR = 1.11 95%-CI 1.03–1.19) and a longer respiratory rate recovery time (OR = 1.12 95%-CI 1.05–1.20) were significant contributors to the probability of having uncontrolled asthma. CONCLUSIONS: Home-monitoring of physiological parameters correlates with paediatrician assessed asthma control. The constructed multivariate model identifies 88.9% of all uncontrolled asthmatic children, indicating a high potential for monitoring of asthma control. This may allow healthcare professionals to assess asthma control at home. TRIAL REGISTRATION: Netherlands Trail Register, NL6087. Registered 14 February 2017.
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spelling pubmed-74277452020-08-17 WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control van der Kamp, M. R. Klaver, E. C. Thio, B. J. Driessen, J. M. M. de Jongh, F. H. C. Tabak, M. van der Palen, J. Hermens, H. J. BMC Med Inform Decis Mak Research Article BACKGROUND: Asthma is one of the most common chronic diseases in childhood. Regular follow-up of physiological parameters in the home setting, in relation to asthma symptoms, can provide complementary quantitative insights into the dynamics of the asthma status. Despite considerable interest in asthma home-monitoring in children, there is a paucity of scientific evidence, especially on multi-parameter monitoring approaches. Therefore, the aim of this study is to investigate whether asthma control can be accurately assessed in the home situation by combining parameters from respiratory physiology sensors. METHODS: Sixty asthmatic and thirty non-asthmatic children were enrolled in the observational WEARCON-study. Asthma control was assessed according to GINA guidelines by the paediatrician. All children were also evaluated during a 2-week home-monitoring period with wearable devices; a physical activity tracker, a handheld spirometer, smart inhalers, and an ambulatory electrocardiography device to monitor heart and respiratory rate. Multiple logistic regression analysis was used to determine which diagnostic measures were associated with asthma control. RESULTS: 24 of the 27 uncontrolled asthmatic children and 29 of the 32 controlled asthmatic children could be accurately identified with this model. The final model showed that a larger variation in pre-exercise lung function (OR = 1.34 95%-CI 1.07–1.68), an earlier wake-up-time (OR = 1.05 95%-CI 1.01–1.10), more reliever use (OR = 1.11 95%-CI 1.03–1.19) and a longer respiratory rate recovery time (OR = 1.12 95%-CI 1.05–1.20) were significant contributors to the probability of having uncontrolled asthma. CONCLUSIONS: Home-monitoring of physiological parameters correlates with paediatrician assessed asthma control. The constructed multivariate model identifies 88.9% of all uncontrolled asthmatic children, indicating a high potential for monitoring of asthma control. This may allow healthcare professionals to assess asthma control at home. TRIAL REGISTRATION: Netherlands Trail Register, NL6087. Registered 14 February 2017. BioMed Central 2020-08-14 /pmc/articles/PMC7427745/ /pubmed/32795352 http://dx.doi.org/10.1186/s12911-020-01210-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
van der Kamp, M. R.
Klaver, E. C.
Thio, B. J.
Driessen, J. M. M.
de Jongh, F. H. C.
Tabak, M.
van der Palen, J.
Hermens, H. J.
WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control
title WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control
title_full WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control
title_fullStr WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control
title_full_unstemmed WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control
title_short WEARCON: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control
title_sort wearcon: wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427745/
https://www.ncbi.nlm.nih.gov/pubmed/32795352
http://dx.doi.org/10.1186/s12911-020-01210-1
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