Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice

Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not be...

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Autores principales: Ke, Zhonghe, Firsanov, Denis, Spencer, Brianna, Seluanov, Andrei, Gorbunova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427781/
https://www.ncbi.nlm.nih.gov/pubmed/32864160
http://dx.doi.org/10.1038/s41514-020-00047-2
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author Ke, Zhonghe
Firsanov, Denis
Spencer, Brianna
Seluanov, Andrei
Gorbunova, Vera
author_facet Ke, Zhonghe
Firsanov, Denis
Spencer, Brianna
Seluanov, Andrei
Gorbunova, Vera
author_sort Ke, Zhonghe
collection PubMed
description Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not been examined in in vivo system. Here we utilize non-homologous end joining (NHEJ) reporter mice to show that short-term CR strongly enhances DNA repair by NHEJ, which is associated with elevated levels of DNA-PK and SIRT6.
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spelling pubmed-74277812020-08-27 Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice Ke, Zhonghe Firsanov, Denis Spencer, Brianna Seluanov, Andrei Gorbunova, Vera NPJ Aging Mech Dis Brief Communication Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not been examined in in vivo system. Here we utilize non-homologous end joining (NHEJ) reporter mice to show that short-term CR strongly enhances DNA repair by NHEJ, which is associated with elevated levels of DNA-PK and SIRT6. Nature Publishing Group UK 2020-08-14 /pmc/articles/PMC7427781/ /pubmed/32864160 http://dx.doi.org/10.1038/s41514-020-00047-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Ke, Zhonghe
Firsanov, Denis
Spencer, Brianna
Seluanov, Andrei
Gorbunova, Vera
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_full Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_fullStr Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_full_unstemmed Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_short Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_sort short-term calorie restriction enhances dna repair by non-homologous end joining in mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427781/
https://www.ncbi.nlm.nih.gov/pubmed/32864160
http://dx.doi.org/10.1038/s41514-020-00047-2
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