Cargando…

An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that is induced in ILC3s during intestinal inflammation. D...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Benyu, Ye, Buqing, Zhu, Xiaoxiao, Yang, Liuliu, Li, Huimu, Liu, Nian, Zhu, Pingping, Lu, Tiankun, He, Luyun, Tian, Yong, Fan, Zusen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427797/ https://www.ncbi.nlm.nih.gov/pubmed/32796851 http://dx.doi.org/10.1038/s41467-020-17944-5

Ejemplares similares

Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription
por: Liu, Benyu, et al.
Publicado: (2019)

IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
por: Liu, Benyu, et al.
Publicado: (2017)

Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription
por: Liu, Nian, et al.
Publicado: (2022)

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling
por: Gu, Yang, et al.
Publicado: (2021)

Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
por: Ye, Buqing, et al.
Publicado: (2018)

circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
por: Chen, Zhenzhen, et al.
Publicado: (2022)

mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs
por: Chen, Zhenzhen, et al.
Publicado: (2023)

Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2
por: Ye, Buqing, et al.
Publicado: (2017)

WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
por: Xia, Pengyan, et al.
Publicado: (2017)

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
por: Zhu, Pingping, et al.
Publicado: (2016)

Antisense oligonucleotide therapy for KCNT1 encephalopathy
por: Burbano, Lisseth Estefania, et al.
Publicado: (2022)

FoxO1-mediated autophagy is required for NK cell development and innate immunity
por: Wang, Shuo, et al.
Publicado: (2016)

Emerging role of the KCNT1 Slack channel in intellectual disability
por: Kim, Grace E., et al.
Publicado: (2014)

Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis
por: Xiong, Zhen, et al.
Publicado: (2019)

Incidence of Aicardi-Goutières syndrome and KCNT1-related epilepsy in Denmark
por: Møller, Rikke S., et al.
Publicado: (2022)

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc–dependent manner
por: Xia, Pengyan, et al.
Publicado: (2014)

Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy
por: McTague, Amy, et al.
Publicado: (2018)

Concurrent Quinidine and Phenobarbital in the Treatment of a Patient with 2 KCNT1 Mutations
por: Passey, Camerin C., et al.
Publicado: (2019)

Epilepsy with migrating focal seizures: KCNT1 mutation hotspots and phenotype variability
por: Barcia, Giulia, et al.
Publicado: (2019)

Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with KCNT1 Genetic Variants
por: Ferretti, Alessandro, et al.
Publicado: (2022)

Cancer stem cells and tumorigenesis
por: Zhu, Pingping, et al.
Publicado: (2018)

CircRNA May Not Be “Circular”
por: Sun, Handong, et al.
Publicado: (2021)

Case Report: Causative De novo Variants of KCNT2 for Developmental and Epileptic Encephalopathy
por: Gong, Pan, et al.
Publicado: (2021)

Zeroing in on Phenotypes While Also Broadening Our Understanding of KCNT1-Related Epilepsy
por: Joshi, Charuta
Publicado: (2022)

MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota
por: Li, Nengneng, et al.
Publicado: (2023)

Quinidine Therapy for Lennox-Gastaut Syndrome With KCNT1 Mutation. A Case Report and Literature Review
por: Jia, Yu, et al.
Publicado: (2019)

The IL-33-ILC2 pathway protects from amebic colitis
por: Uddin, Md Jashim, et al.
Publicado: (2021)

Slick (Kcnt2) Sodium-Activated Potassium Channels Limit Peptidergic Nociceptor Excitability and Hyperalgesia
por: Tomasello, Danielle L, et al.
Publicado: (2017)

Mild malformations of cortical development in sleep‐related hypermotor epilepsy due to KCNT1 mutations
por: Rubboli, Guido, et al.
Publicado: (2018)

Autosomal dominant sleep-related hypermotor epilepsy associated with a novel mutation of KCNT1
por: Lu, Jinyu, et al.
Publicado: (2022)

Exosomal circular RNA hsa_circ_0006220, and hsa_circ_0001666 as biomarkers in the diagnosis of pancreatic cancer
por: Hong, Lu, et al.
Publicado: (2022)

A circular RNA circ_0000115 in response to graphene oxide in nematodes
por: Shi, Lifang, et al.
Publicado: (2019)

A novel KCNT1 mutation in a Japanese patient with epilepsy of infancy with migrating focal seizures
por: Shimada, Shino, et al.
Publicado: (2014)

Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy
por: Gertler, Tracy S., et al.
Publicado: (2019)

Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies
por: Yamamoto, Kaoru, et al.
Publicado: (2023)

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy
por: Hill, Sophie F., et al.
Publicado: (2023)

ILC
por: Stanitzki, Marcel
Publicado: (2018)

CircSMARCA5: A key circular RNA in various human diseases
por: Zhu, Yi, et al.
Publicado: (2022)

Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer
por: Yang, Fan, et al.
Publicado: (2017)

Functional Effects of Epilepsy Associated KCNT1 Mutations Suggest Pathogenesis via Aberrant Inhibitory Neuronal Activity
por: Rychkov, Grigori Y., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_84jpkks0ub6j78pn3n52u1oil9