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Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study

BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes. The results remain inconsistent and require further exploration. METHODS: A total of 2814 Chinese mother-infant pairs were included in this retrospect...

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Autores principales: Chen, Geng-dong, Pang, Ting-ting, Li, Peng-sheng, Zhou, Zi-xing, Lin, Dong-xin, Fan, Da-zhi, Guo, Xiao-ling, Liu, Zheng-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427871/
https://www.ncbi.nlm.nih.gov/pubmed/32795269
http://dx.doi.org/10.1186/s12884-020-03158-6
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author Chen, Geng-dong
Pang, Ting-ting
Li, Peng-sheng
Zhou, Zi-xing
Lin, Dong-xin
Fan, Da-zhi
Guo, Xiao-ling
Liu, Zheng-ping
author_facet Chen, Geng-dong
Pang, Ting-ting
Li, Peng-sheng
Zhou, Zi-xing
Lin, Dong-xin
Fan, Da-zhi
Guo, Xiao-ling
Liu, Zheng-ping
author_sort Chen, Geng-dong
collection PubMed
description BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes. The results remain inconsistent and require further exploration. METHODS: A total of 2814 Chinese mother-infant pairs were included in this retrospective cohort study. Serum concentrations of 25(OH)D were reviewed in early pregnancy (16.3 ± 2.3 weeks). Outcomes of maternal gestational diabetes mellitus (GDM), cesarean section, fetal distress, preterm birth, low birth weight (LBW), and macrosomia were extracted from the medical records. Cox regression analysis was used to explore these associations. RESULTS: In total, 19.3% of mothers were pregnant at an advanced age (≥35 years), and 40.3% of pregnant women had vitamin D deficiency (< 50 nmol/L). After adjusting for potential covariates, the hazard ratio (HR) (95% CI) per standard deviation (SD) increase of serum 25(OH)D concentrations was 0.86 (0.779, 0.951) for GDM, 0.844 (0.730, 0.976) for preterm birth, and 0.849 (0.726, 0.993) for LBW. Similar protective associations were found for GDM, cesarean section, and preterm birth for a better vitamin D status when compared with vitamin D deficiency. CONCLUSION: Higher early pregnancy vitamin D was associated with a lower risk of GDM, cesarean section, preterm birth, and LBW.
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spelling pubmed-74278712020-08-17 Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study Chen, Geng-dong Pang, Ting-ting Li, Peng-sheng Zhou, Zi-xing Lin, Dong-xin Fan, Da-zhi Guo, Xiao-ling Liu, Zheng-ping BMC Pregnancy Childbirth Research Article BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes. The results remain inconsistent and require further exploration. METHODS: A total of 2814 Chinese mother-infant pairs were included in this retrospective cohort study. Serum concentrations of 25(OH)D were reviewed in early pregnancy (16.3 ± 2.3 weeks). Outcomes of maternal gestational diabetes mellitus (GDM), cesarean section, fetal distress, preterm birth, low birth weight (LBW), and macrosomia were extracted from the medical records. Cox regression analysis was used to explore these associations. RESULTS: In total, 19.3% of mothers were pregnant at an advanced age (≥35 years), and 40.3% of pregnant women had vitamin D deficiency (< 50 nmol/L). After adjusting for potential covariates, the hazard ratio (HR) (95% CI) per standard deviation (SD) increase of serum 25(OH)D concentrations was 0.86 (0.779, 0.951) for GDM, 0.844 (0.730, 0.976) for preterm birth, and 0.849 (0.726, 0.993) for LBW. Similar protective associations were found for GDM, cesarean section, and preterm birth for a better vitamin D status when compared with vitamin D deficiency. CONCLUSION: Higher early pregnancy vitamin D was associated with a lower risk of GDM, cesarean section, preterm birth, and LBW. BioMed Central 2020-08-14 /pmc/articles/PMC7427871/ /pubmed/32795269 http://dx.doi.org/10.1186/s12884-020-03158-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Chen, Geng-dong
Pang, Ting-ting
Li, Peng-sheng
Zhou, Zi-xing
Lin, Dong-xin
Fan, Da-zhi
Guo, Xiao-ling
Liu, Zheng-ping
Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study
title Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study
title_full Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study
title_fullStr Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study
title_full_unstemmed Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study
title_short Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study
title_sort early pregnancy vitamin d and the risk of adverse maternal and infant outcomes: a retrospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427871/
https://www.ncbi.nlm.nih.gov/pubmed/32795269
http://dx.doi.org/10.1186/s12884-020-03158-6
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