Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

Single nucleotide polymorphisms (SNPs) in the gene encoding kinesin family member 3A, KIF3A, have been associated with atopic dermatitis (AD), a chronic inflammatory skin disorder. We find that KIF3A SNP rs11740584 and rs2299007 risk alleles create cytosine-phosphate-guanine sites, which are highly...

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Detalles Bibliográficos
Autores principales: Stevens, Mariana L., Zhang, Zhonghua, Johansson, Elisabet, Ray, Samriddha, Jagpal, Amrita, Ruff, Brandy P., Kothari, Arjun, He, Hua, Martin, Lisa J., Ji, Hong, Wikenheiser-Brokamp, Kathryn, Weirauch, Matthew T., Supp, Dorothy M., Biagini Myers, Jocelyn M., Khurana Hershey, Gurjit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427989/
https://www.ncbi.nlm.nih.gov/pubmed/32796837
http://dx.doi.org/10.1038/s41467-020-17895-x

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