A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 ade...

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Autores principales: Wu, Shipo, Zhong, Gongxun, Zhang, Jun, Shuai, Lei, Zhang, Zhe, Wen, Zhiyuan, Wang, Busen, Zhao, Zhenghao, Song, Xiaohong, Chen, Yi, Liu, Renqiang, Fu, Ling, Zhang, Jinlong, Guo, Qiang, Wang, Chong, Yang, Yilong, Fang, Ting, Lv, Peng, Wang, Jinliang, Xu, Junjie, Li, Jianmin, Yu, Changming, Hou, Lihua, Bu, Zhigao, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427994/
https://www.ncbi.nlm.nih.gov/pubmed/32796842
http://dx.doi.org/10.1038/s41467-020-17972-1
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author Wu, Shipo
Zhong, Gongxun
Zhang, Jun
Shuai, Lei
Zhang, Zhe
Wen, Zhiyuan
Wang, Busen
Zhao, Zhenghao
Song, Xiaohong
Chen, Yi
Liu, Renqiang
Fu, Ling
Zhang, Jinlong
Guo, Qiang
Wang, Chong
Yang, Yilong
Fang, Ting
Lv, Peng
Wang, Jinliang
Xu, Junjie
Li, Jianmin
Yu, Changming
Hou, Lihua
Bu, Zhigao
Chen, Wei
author_facet Wu, Shipo
Zhong, Gongxun
Zhang, Jun
Shuai, Lei
Zhang, Zhe
Wen, Zhiyuan
Wang, Busen
Zhao, Zhenghao
Song, Xiaohong
Chen, Yi
Liu, Renqiang
Fu, Ling
Zhang, Jinlong
Guo, Qiang
Wang, Chong
Yang, Yilong
Fang, Ting
Lv, Peng
Wang, Jinliang
Xu, Junjie
Li, Jianmin
Yu, Changming
Hou, Lihua
Bu, Zhigao
Chen, Wei
author_sort Wu, Shipo
collection PubMed
description The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.
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spelling pubmed-74279942020-08-28 A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge Wu, Shipo Zhong, Gongxun Zhang, Jun Shuai, Lei Zhang, Zhe Wen, Zhiyuan Wang, Busen Zhao, Zhenghao Song, Xiaohong Chen, Yi Liu, Renqiang Fu, Ling Zhang, Jinlong Guo, Qiang Wang, Chong Yang, Yilong Fang, Ting Lv, Peng Wang, Jinliang Xu, Junjie Li, Jianmin Yu, Changming Hou, Lihua Bu, Zhigao Chen, Wei Nat Commun Article The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials. Nature Publishing Group UK 2020-08-14 /pmc/articles/PMC7427994/ /pubmed/32796842 http://dx.doi.org/10.1038/s41467-020-17972-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wu, Shipo
Zhong, Gongxun
Zhang, Jun
Shuai, Lei
Zhang, Zhe
Wen, Zhiyuan
Wang, Busen
Zhao, Zhenghao
Song, Xiaohong
Chen, Yi
Liu, Renqiang
Fu, Ling
Zhang, Jinlong
Guo, Qiang
Wang, Chong
Yang, Yilong
Fang, Ting
Lv, Peng
Wang, Jinliang
Xu, Junjie
Li, Jianmin
Yu, Changming
Hou, Lihua
Bu, Zhigao
Chen, Wei
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_full A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_fullStr A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_full_unstemmed A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_short A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
title_sort single dose of an adenovirus-vectored vaccine provides protection against sars-cov-2 challenge
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427994/
https://www.ncbi.nlm.nih.gov/pubmed/32796842
http://dx.doi.org/10.1038/s41467-020-17972-1
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