Cargando…

Muscarinic receptors promote castration resistant growth of prostate cancer through a FAK-YAP signaling axis

Prostate cancer innervation contributes to the progression of prostate cancer (PCa). However, the precise impact of innervation on PCa cells is still poorly understood. By focusing on muscarinic receptors, which are activated by the nerve-derived neurotransmitter acetylcholine, we show that muscarin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goto, Yusuke, Ando, Toshinori, Izumi, Hiroki, Feng, Xiaodong, Arang, Nadia, Gilardi, Mara, Wang, Zhiyong, Ando, Kazuyo, Gutkind, J. Silvio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428076/ https://www.ncbi.nlm.nih.gov/pubmed/32205868 http://dx.doi.org/10.1038/s41388-020-1272-x

Ejemplares similares

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
por: Ando, Toshinori, et al.
Publicado: (2021)

Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)
por: Rigiracciolo, Damiano Cosimo, et al.
Publicado: (2022)

IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells
por: Rigiracciolo, Damiano Cosimo, et al.
Publicado: (2020)

Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling
por: Gao, Jiaming, et al.
Publicado: (2023)

Correction: Rigiracciolo, D.C., et al., IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells 2020, 9, 1010
por: Rigiracciolo, Damiano Cosimo, et al.
Publicado: (2020)

Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine
por: Ando, Toshinori, et al.
Publicado: (2022)

Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
por: Wang, Zhiyong, et al.
Publicado: (2021)

Exploring the influence of cytosolic and membrane FAK activation on YAP/TAZ nuclear translocation
por: Eroumé, Kerbaï Saïd, et al.
Publicado: (2021)

Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling
por: Zhang, Baoyuan, et al.
Publicado: (2021)

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry
por: Arang, Nadia, et al.
Publicado: (2022)

Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer
por: Faraji, Farhoud, et al.
Publicado: (2022)

YAP is closely correlated with castration-resistant prostate cancer, and downregulation of YAP reduces proliferation and induces apoptosis of PC-3 cells
por: SHENG, XIA, et al.
Publicado: (2015)

Graphene-Induced Osteogenic Differentiation Is Mediated by the Integrin/FAK Axis
por: Xie, Han, et al.
Publicado: (2019)

P130cas-FAK interaction is essential for YAP-mediated radioresistance of non-small cell lung cancer
por: Li, Jingduo, et al.
Publicado: (2022)

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
por: Sato, Tadatoshi, et al.
Publicado: (2020)

Clutching at Guidance Cues: The Integrin–FAK Axis Steers Axon Outgrowth
por: Davis-Lunn, Mathew, et al.
Publicado: (2023)

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
por: Liu, Shu-Chen, et al.
Publicado: (2018)

SEMA6C: a novel adhesion-independent FAK and YAP activator, required for cancer cell viability and growth
por: Fard, Damon, et al.
Publicado: (2023)

Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor
por: Buigues, Pedro J., et al.
Publicado: (2023)

Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER(+) breast cancer
por: Ma, Shenghong, et al.
Publicado: (2022)

YAP1 regulates prostate cancer stem cell-like characteristics to promote castration resistant growth
por: Jiang, Ning, et al.
Publicado: (2017)

MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer
por: Li, Qiji, et al.
Publicado: (2021)

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer
por: Shen, Jie, et al.
Publicado: (2018)

Backtracking on FAK
por: Leslie, Mitch
Publicado: (2008)

FAK monitoring
por: Metzmacher, K D
Publicado: (1974)

Muscarinic receptor oligomerization
por: Marsango, Sara, et al.
Publicado: (2018)

Oncotargeting G proteins: The Hippo in the room
por: Feng, Xiaodong, et al.
Publicado: (2014)

Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis
por: Ozmadenci, Duygu, et al.
Publicado: (2022)

Correction: Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signaling in breast cancer
por: Shen, Jie, et al.
Publicado: (2023)

Castration-Resistant Prostate Cancer Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents: Opportunities and Challenges
por: Kita, Yuki, et al.
Publicado: (2018)

Prognostic Value of High-Sensitivity Modified Glasgow Prognostic Score in Castration-Resistant Prostate Cancer Patients Who Received Docetaxel
por: Ando, Keisuke, et al.
Publicado: (2021)

(Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis
por: Yoshida, Naohiro, et al.
Publicado: (2019)

Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy
por: Xu, B, et al.
Publicado: (2017)

Optimal treatment for castration-resistant prostate cancer
por: Izumi, Kouji, et al.
Publicado: (2014)

The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis
por: Golubovskaya, Vita M, et al.
Publicado: (2009)

YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution
por: Gutkind, J. Silvio, et al.
Publicado: (2023)

Muscarinic Receptor Agonists and Antagonists
por: Broadley, Kenneth J., et al.
Publicado: (2001)

Muscarinic Receptors Associated with Cancer
por: Calaf, Gloria M., et al.
Publicado: (2022)

The SRF-YAP-IL6 axis promotes breast cancer stemness
por: Kim, Tackhoon, et al.
Publicado: (2016)

Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer
por: Wang, Tianshi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lkgjsh7i130hhp7dk8esk87eec