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Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics

Glioblastoma (GBM) is the most aggressive malignant primary brain tumour with a median overall survival of 15 months. To treat GBM, patients currently undergo a surgical resection followed by exposure to radiotherapy and concurrent and adjuvant temozolomide (TMZ) chemotherapy. However, this protocol...

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Detalles Bibliográficos
Autores principales:	Lasri, Ayoub, Juric, Viktorija, Verreault, Maité, Bielle, Franck, Idbaih, Ahmed, Kel, Alexander, Murphy, Brona, Sturrock, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2020
Materias:	Mathematics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428254/ https://www.ncbi.nlm.nih.gov/pubmed/32874597 http://dx.doi.org/10.1098/rsos.191243

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