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Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients
Graphene oxide (GO) is a derivative of graphene nanosheet which is the most promising material of the decade in biomedical research. In particular, it has been known as an antimicrobial nanomaterial with good biocompatibility. In this study, we have synthesized and characterize GO and checked its an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428267/ https://www.ncbi.nlm.nih.gov/pubmed/32874659 http://dx.doi.org/10.1098/rsos.200640 |
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author | Aunkor, Md. Toasin Hossain Raihan, Topu Prodhan, Shamsul H. Metselaar, H. S. C. Malik, Syeda Umme Fahmida Azad, Abul Kalam |
author_facet | Aunkor, Md. Toasin Hossain Raihan, Topu Prodhan, Shamsul H. Metselaar, H. S. C. Malik, Syeda Umme Fahmida Azad, Abul Kalam |
author_sort | Aunkor, Md. Toasin Hossain |
collection | PubMed |
description | Graphene oxide (GO) is a derivative of graphene nanosheet which is the most promising material of the decade in biomedical research. In particular, it has been known as an antimicrobial nanomaterial with good biocompatibility. In this study, we have synthesized and characterize GO and checked its antimicrobial property against different Gram-negative and Gram-positive multidrug drug resistant (MDR) hospital superbugs grown in solid agar-based nutrient plates with and without human serum through the utilization of agar well diffusion method, live/dead fluorescent staining and genotoxicity analysis. No significant changes in antibacterial activity were found in these two different conditions. We also compare the bactericidal capability of GO with some commonly administered antibiotics and in all cases the degree of inhibition is found to be higher. The data presented here are novel and show that GO is an effective bactericidal agent against different superbugs and can be used as a future antibacterial agent. |
format | Online Article Text |
id | pubmed-7428267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-74282672020-08-31 Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients Aunkor, Md. Toasin Hossain Raihan, Topu Prodhan, Shamsul H. Metselaar, H. S. C. Malik, Syeda Umme Fahmida Azad, Abul Kalam R Soc Open Sci Chemistry Graphene oxide (GO) is a derivative of graphene nanosheet which is the most promising material of the decade in biomedical research. In particular, it has been known as an antimicrobial nanomaterial with good biocompatibility. In this study, we have synthesized and characterize GO and checked its antimicrobial property against different Gram-negative and Gram-positive multidrug drug resistant (MDR) hospital superbugs grown in solid agar-based nutrient plates with and without human serum through the utilization of agar well diffusion method, live/dead fluorescent staining and genotoxicity analysis. No significant changes in antibacterial activity were found in these two different conditions. We also compare the bactericidal capability of GO with some commonly administered antibiotics and in all cases the degree of inhibition is found to be higher. The data presented here are novel and show that GO is an effective bactericidal agent against different superbugs and can be used as a future antibacterial agent. The Royal Society 2020-07-15 /pmc/articles/PMC7428267/ /pubmed/32874659 http://dx.doi.org/10.1098/rsos.200640 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Chemistry Aunkor, Md. Toasin Hossain Raihan, Topu Prodhan, Shamsul H. Metselaar, H. S. C. Malik, Syeda Umme Fahmida Azad, Abul Kalam Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients |
title | Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients |
title_full | Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients |
title_fullStr | Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients |
title_full_unstemmed | Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients |
title_short | Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients |
title_sort | antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428267/ https://www.ncbi.nlm.nih.gov/pubmed/32874659 http://dx.doi.org/10.1098/rsos.200640 |
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