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Modelling of the arteriovenous malformation embolization optimal scenario
Cerebral arteriovenous malformation (AVM) is a congenital brain vessels pathology, in which the arterial and venous blood channels are connected by tangles of abnormal blood vessels. It is a dangerous disease that affects brain functioning causing the high risk of intracerebral haemorrhage. One of A...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428277/ https://www.ncbi.nlm.nih.gov/pubmed/32874606 http://dx.doi.org/10.1098/rsos.191992 |
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author | Cherevko, Alexandr A. Gologush, Tatiana S. Petrenko, Irina A. Ostapenko, Vladimir V. Panarin, Vyacheslav A. |
author_facet | Cherevko, Alexandr A. Gologush, Tatiana S. Petrenko, Irina A. Ostapenko, Vladimir V. Panarin, Vyacheslav A. |
author_sort | Cherevko, Alexandr A. |
collection | PubMed |
description | Cerebral arteriovenous malformation (AVM) is a congenital brain vessels pathology, in which the arterial and venous blood channels are connected by tangles of abnormal blood vessels. It is a dangerous disease that affects brain functioning causing the high risk of intracerebral haemorrhage. One of AVM treatment methods is embolization—the endovascular filling of the AVM vessel bundle with a special embolic agent. This method is widely used, but still in some cases is accompanied by intraoperative AVM vessels rupture. In this paper, the optimal scenario of AVM embolization is studied from the safety and effectiveness of the procedure point of view. The co-movement of blood and embolic agent in the AVM body is modelled on the basis of a one-dimensional two-phase filtration model. Optimal control problem with phase constraints arising from medicine is formulated and numerically solved. In numerical analysis, the monotone modification of the CABARET scheme is used. Optimal embolization model is constructed on the basis of real patients' clinical data collected during neurosurgical operations. For the special case of embolic agent, input admissible and optimal embolization scenarios were calculated. |
format | Online Article Text |
id | pubmed-7428277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-74282772020-08-31 Modelling of the arteriovenous malformation embolization optimal scenario Cherevko, Alexandr A. Gologush, Tatiana S. Petrenko, Irina A. Ostapenko, Vladimir V. Panarin, Vyacheslav A. R Soc Open Sci Mathematics Cerebral arteriovenous malformation (AVM) is a congenital brain vessels pathology, in which the arterial and venous blood channels are connected by tangles of abnormal blood vessels. It is a dangerous disease that affects brain functioning causing the high risk of intracerebral haemorrhage. One of AVM treatment methods is embolization—the endovascular filling of the AVM vessel bundle with a special embolic agent. This method is widely used, but still in some cases is accompanied by intraoperative AVM vessels rupture. In this paper, the optimal scenario of AVM embolization is studied from the safety and effectiveness of the procedure point of view. The co-movement of blood and embolic agent in the AVM body is modelled on the basis of a one-dimensional two-phase filtration model. Optimal control problem with phase constraints arising from medicine is formulated and numerically solved. In numerical analysis, the monotone modification of the CABARET scheme is used. Optimal embolization model is constructed on the basis of real patients' clinical data collected during neurosurgical operations. For the special case of embolic agent, input admissible and optimal embolization scenarios were calculated. The Royal Society 2020-07-22 /pmc/articles/PMC7428277/ /pubmed/32874606 http://dx.doi.org/10.1098/rsos.191992 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Mathematics Cherevko, Alexandr A. Gologush, Tatiana S. Petrenko, Irina A. Ostapenko, Vladimir V. Panarin, Vyacheslav A. Modelling of the arteriovenous malformation embolization optimal scenario |
title | Modelling of the arteriovenous malformation embolization optimal scenario |
title_full | Modelling of the arteriovenous malformation embolization optimal scenario |
title_fullStr | Modelling of the arteriovenous malformation embolization optimal scenario |
title_full_unstemmed | Modelling of the arteriovenous malformation embolization optimal scenario |
title_short | Modelling of the arteriovenous malformation embolization optimal scenario |
title_sort | modelling of the arteriovenous malformation embolization optimal scenario |
topic | Mathematics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428277/ https://www.ncbi.nlm.nih.gov/pubmed/32874606 http://dx.doi.org/10.1098/rsos.191992 |
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