Altered 3D chromatin structure permits inversional recombination at the IgH locus

Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG) 1 and 2. Diversity (D(H)) gene segments rearrange first, followed by variable (V(H)) gene rearrangements. Here, we provide evidence that...

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Detalles Bibliográficos
Autores principales: Qiu, Xiang, Ma, Fei, Zhao, Mingming, Cao, Yaqiang, Shipp, Lillian, Liu, Angela, Dutta, Arun, Singh, Amit, Braikia, Fatima Zohra, De, Supriyo, Wood, William H., Becker, Kevin G., Zhou, Weiqiang, Ji, Hongkai, Zhao, Keji, Atchison, Michael L., Sen, Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428332/
https://www.ncbi.nlm.nih.gov/pubmed/32851160
http://dx.doi.org/10.1126/sciadv.aaz8850

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