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EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution
OBJECTIVE: In multiplex MS families, we determined the humoral immune response to Epstein-Barr virus nuclear antigen 1 (EBNA-1)-specific immunoglobulin γ (IgG) titers in patients with MS, their healthy siblings, and biologically unrelated healthy spouses and investigated the role of specific genetic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428359/ https://www.ncbi.nlm.nih.gov/pubmed/32796079 http://dx.doi.org/10.1212/NXI.0000000000000872 |
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author | Mescheriakova, Julia Y. van Nierop, Gijsbert P. van der Eijk, Annemiek A. Kreft, Karim L. Hintzen, Rogier Q. |
author_facet | Mescheriakova, Julia Y. van Nierop, Gijsbert P. van der Eijk, Annemiek A. Kreft, Karim L. Hintzen, Rogier Q. |
author_sort | Mescheriakova, Julia Y. |
collection | PubMed |
description | OBJECTIVE: In multiplex MS families, we determined the humoral immune response to Epstein-Barr virus nuclear antigen 1 (EBNA-1)-specific immunoglobulin γ (IgG) titers in patients with MS, their healthy siblings, and biologically unrelated healthy spouses and investigated the role of specific genetic loci on the antiviral IgG titers. METHODS: IgG levels against EBNA-1 and varicella zoster virus (VZV) as control were measured. HLA-DRB1*1501 and HLA-A*02 tagging single-nucleotide polymorphisms (SNPs) were genotyped. We assessed the associations between these SNPs and antiviral IgG titers. RESULTS: OR for abundant EBNA-1 IgG was the highest in patients with MS and intermediate in their siblings compared with spouses. We confirmed that HLA-DRB1*1501 is associated with abundant EBNA-1 IgG. After stratification for HLA-DRB1*1501, the EBNA-1 IgG gradient was still significant in patients with MS and young siblings compared with spouses. HLA-A*02 was not explanatory for EBNA-1 IgG titer gradient. No associations for VZV IgG were found. CONCLUSIONS: In families with MS, the EBNA-1 IgG gradient being the highest in patients with MS, intermediate in their siblings, and lowest in biologically unrelated spouses indicates a genetic contribution to EBNA-1 IgG levels that is only partially explained by HLA-DRB1*1501 carriership. |
format | Online Article Text |
id | pubmed-7428359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-74283592020-08-25 EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution Mescheriakova, Julia Y. van Nierop, Gijsbert P. van der Eijk, Annemiek A. Kreft, Karim L. Hintzen, Rogier Q. Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: In multiplex MS families, we determined the humoral immune response to Epstein-Barr virus nuclear antigen 1 (EBNA-1)-specific immunoglobulin γ (IgG) titers in patients with MS, their healthy siblings, and biologically unrelated healthy spouses and investigated the role of specific genetic loci on the antiviral IgG titers. METHODS: IgG levels against EBNA-1 and varicella zoster virus (VZV) as control were measured. HLA-DRB1*1501 and HLA-A*02 tagging single-nucleotide polymorphisms (SNPs) were genotyped. We assessed the associations between these SNPs and antiviral IgG titers. RESULTS: OR for abundant EBNA-1 IgG was the highest in patients with MS and intermediate in their siblings compared with spouses. We confirmed that HLA-DRB1*1501 is associated with abundant EBNA-1 IgG. After stratification for HLA-DRB1*1501, the EBNA-1 IgG gradient was still significant in patients with MS and young siblings compared with spouses. HLA-A*02 was not explanatory for EBNA-1 IgG titer gradient. No associations for VZV IgG were found. CONCLUSIONS: In families with MS, the EBNA-1 IgG gradient being the highest in patients with MS, intermediate in their siblings, and lowest in biologically unrelated spouses indicates a genetic contribution to EBNA-1 IgG levels that is only partially explained by HLA-DRB1*1501 carriership. Lippincott Williams & Wilkins 2020-08-13 /pmc/articles/PMC7428359/ /pubmed/32796079 http://dx.doi.org/10.1212/NXI.0000000000000872 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Article Mescheriakova, Julia Y. van Nierop, Gijsbert P. van der Eijk, Annemiek A. Kreft, Karim L. Hintzen, Rogier Q. EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution |
title | EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution |
title_full | EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution |
title_fullStr | EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution |
title_full_unstemmed | EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution |
title_short | EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution |
title_sort | ebna-1 titer gradient in families with multiple sclerosis indicates a genetic contribution |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428359/ https://www.ncbi.nlm.nih.gov/pubmed/32796079 http://dx.doi.org/10.1212/NXI.0000000000000872 |
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