Cargando…

EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution

OBJECTIVE: In multiplex MS families, we determined the humoral immune response to Epstein-Barr virus nuclear antigen 1 (EBNA-1)-specific immunoglobulin γ (IgG) titers in patients with MS, their healthy siblings, and biologically unrelated healthy spouses and investigated the role of specific genetic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mescheriakova, Julia Y., van Nierop, Gijsbert P., van der Eijk, Annemiek A., Kreft, Karim L., Hintzen, Rogier Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428359/ https://www.ncbi.nlm.nih.gov/pubmed/32796079 http://dx.doi.org/10.1212/NXI.0000000000000872

Ejemplares similares

Elevated EBNA-1 IgG in MS is associated with genetic MS risk variants
por: Kreft, Karim L., et al.
Publicado: (2017)

Burden of genetic risk variants in multiple sclerosis families in the Netherlands
por: Mescheriakova, Julia Y, et al.
Publicado: (2016)

Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family
por: Mescheriakova, Julia Y, et al.
Publicado: (2018)

Smoking at time of CIS increases the risk of clinically definite multiple sclerosis
por: van der Vuurst de Vries, Roos M., et al.
Publicado: (2018)

Fatigue after a first attack of suspected multiple sclerosis
por: van der Vuurst de Vries, Roos M, et al.
Publicado: (2017)

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients
por: van Nierop, Gijsbert P., et al.
Publicado: (2017)

Axonal transport deficits in multiple sclerosis: spiraling into the abyss
por: van den Berg, Robert, et al.
Publicado: (2017)

High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome
por: van der Vuurst de Vries, Roos M, et al.
Publicado: (2018)

Perspectives on the Use of Multiple Sclerosis Risk Genes for Prediction
por: Jafari, Naghmeh, et al.
Publicado: (2011)

Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation
por: Huizinga, Ruth, et al.
Publicado: (2012)

ERK2 phosphorylation of EBNA1 serine 383 residue is important for EBNA1-dependent transactivation
por: Noh, Ka-Won, et al.
Publicado: (2016)

Mapping an epitope in EBNA‐1 that is recognized by monoclonal antibodies to EBNA‐1 that cross‐react with dsDNA
por: Yadav, Pragya, et al.
Publicado: (2016)

EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells
por: Glaser, Laura V., et al.
Publicado: (2017)

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
por: Thomas, Olivia G., et al.
Publicado: (2023)

Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry
por: Siepman, Theodora A. M., et al.
Publicado: (2010)

Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival
por: Frappier, Lori
Publicado: (2012)

Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis
por: Toussaint-Duyster, Leontien CC, et al.
Publicado: (2017)

Murine Cytotoxic T Lymphocytes Recognize an Epitope in an EBNA-1 Fragment, but Fail to Lyse EBNA-1–expressing Mouse Cells
por: Mukherjee, Siddhartha, et al.
Publicado: (1998)

EBNA2 Binds to Genomic Intervals Associated with Multiple Sclerosis and Overlaps with Vitamin D Receptor Occupancy
por: Ricigliano, Vito A. G., et al.
Publicado: (2015)

The Epstein-Barr Virus EBNA1 Protein
por: Frappier, Lori
Publicado: (2012)

Abundant kif21b is associated with accelerated progression in neurodegenerative diseases
por: Kreft, Karim L, et al.
Publicado: (2014)

Dissecting the contribution of EBNA3C domains important for EBV-induced B-cell growth and proliferation
por: Jha, Hem Chandra, et al.
Publicado: (2015)

A High Prevalence of Anti-EBNA1 Heteroantibodies in Systemic Lupus Erythematosus (SLE) Supports Anti-EBNA1 as an Origin for SLE Autoantibodies
por: Laurynenka, Viktoryia, et al.
Publicado: (2022)

EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls
por: Monaco, Maria Chiara G., et al.
Publicado: (2023)

Gray matter–related proteins are associated with childhood-onset multiple sclerosis
por: Singh, Vaibhav, et al.
Publicado: (2015)

Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts EBNA2 activity
por: Ponnusamy, Rajesh, et al.
Publicado: (2019)

The interaction of Epstein-Barr virus encoded transcription factor EBNA2 with multiple sclerosis risk loci is dependent on the risk genotype
por: Keane, Jeremy Thomas, et al.
Publicado: (2021)

Epigenetic Repression of p16(INK4A) by Latent Epstein-Barr Virus Requires the Interaction of EBNA3A and EBNA3C with CtBP
por: Skalska, Lenka, et al.
Publicado: (2010)

Induction of brain‐infiltrating T‐bet–expressing B cells in multiple sclerosis
por: van Langelaar, Jamie, et al.
Publicado: (2019)

BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2
por: Harter, Matthew R., et al.
Publicado: (2016)

T-cell activation marker sCD27 is associated with clinically definite multiple sclerosis in childhood-acquired demyelinating syndromes
por: Wong, Yu Yi M, et al.
Publicado: (2018)

The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency
por: Styles, Christine T., et al.
Publicado: (2018)

Molecular Screening for Epstein-Barr virus (EBV): Detection of Genomic EBNA-1, EBNA-2, LMP-1, LMP-2 Among Vietnamese Patients with Nasopharyngeal Brush Samples
por: Lao, Thuan Duc, et al.
Publicado: (2017)

Interpretation and Visualization of Non-Linear Data Fusion in Kernel Space: Study on Metabolomic Characterization of Progression of Multiple Sclerosis
por: Smolinska, Agnieszka, et al.
Publicado: (2012)

The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis
por: Rijvers, Liza, et al.
Publicado: (2018)

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2
por: Lünemann, Jan D., et al.
Publicado: (2008)

Antibodies Elicited in Response to EBNA-1 May Cross-React with dsDNA
por: Yadav, Pragya, et al.
Publicado: (2011)

EBNA3C interacts with Gadd34 and counteracts the unfolded protein response
por: Garrido, Jose L, et al.
Publicado: (2009)

Role of EBNA-3 Family Proteins in EBV Associated B-cell Lymphomagenesis
por: Bhattacharjee, Shaoni, et al.
Publicado: (2016)

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
por: Harley, John B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mngg8f1l4vn9ctb0nuhefcajrb